Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.

NCT03476668 | Completed DMC

• 1 other identifier: MIRT-RTs-Laterality
• Study Type: interventional
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).

Conditions

Parkinson Disease; Attention Disturbances

Outcome Measures

Primary Outcomes (3)

• Visual Reaction Times (V RTs)

  Visual Reaction Times

  4 weeks

• Auditory Reaction Times (A RTs)

  Auditory Reaction Times

  4 weeks

• Multiple Choices RTs (MC RTs)

  Multiple Choices RTs

  4 weeks

Secondary Outcomes (2)

• Unified Parkinson's Disease Rating Scale (UPDRS)

  4 weeks

• Timed Up and Go Test (TUG)

  4 weeks

Study Arms (2)

RPD PD patients

ACTIVE COMPARATOR

Right-side affected PD patients. Intervention: MIRT

Other: MIRT

LPD PD patients

ACTIVE COMPARATOR

Left-side affected (LPD) PD patients. Intervention: MIRT

Other: MIRT

Interventions

MIRT OTHER

4-week multidisciplinary intensive rehabilitation treatment

LPD PD patients; RPD PD patients

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Stage 2.5-3 according to the Hoehn and Yahr scale (H\&Y);
• Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
• Mini Mental State Examination (MMSE) ≥ 24;
• No evidences of dysexecutive syndrome.

You may not qualify if:

• Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
• Drug-induced dyskinesias;
• Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
• Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
• Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
• Equivocal report about the side of disease onset or bilateral motor involvement.

Sponsors & Collaborators

• Ospedale Generale Di Zona Moriggia-Pelascini: lead

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Giuseppe Frazzitta, MD

  epartment of Parkinson's disease, Movement Disorders and Brain Injury Rehabilitation, "Moriggia-Pelascini" Hospital - Via Pelascini, 3, 22015, Gravedona ed Uniti, Como, Italy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 19, 2018
• First Posted: March 26, 2018
• Study Start: January 1, 2017
• Primary Completion: August 1, 2017
• Study Completion: August 1, 2017
• Last Updated: May 30, 2018

Record last verified: 2018-05

Data Sharing

• IPD Sharing: Will not share