Treatment Adherence and Blood Pressure Outcome Among Hypertensive Out-patients

NCT03476512 | Completed

• 1 other identifier: TAHYP001
• Study Type: observational
• Target: 605
• Locations: 1 country
• Sites: 1

Brief Summary

It is estimated that more than 70% of patients on antihypertensive medications do not take them as prescribed. Treatment non-adherence practice may be particularly higher in developing countries where there is poor accessibility to medicines and healthcare services, coupled with low level of awareness of the lifelong nature of hypertension treatment among patients. Optimal control of blood pressure has been reported to reduce the incidence of morbidity and mortality associated with hypertension. Thus, adoption of healthy lifestyle as well as ensuring regular and continuous adherence to prescribed medications are integral to successful management of hypertension to achieve the target blood pressure goals. The present study comprehensively evaluated adherence to pharmacotherapy and non-pharmacological measures among ambulatory hypertensive patients attending two healthcare institutions in Sokoto, Northwestern Nigeria. Reasons for treatment non-adherence were evaluated, while perception and beliefs about hypertension and its management were also explored, with pharmacist-led patient-specific adherence education provided as appropriate to resolve the knowledge gap(s). Association between treatment adherence and blood pressure outcome at contact and the subsequent 2-months clinic appointment were investigated. Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on antihypertensive medications for at least 3-months were recruited from the medical outpatient clinic of Usmanu Danfodiyo University Teaching Hospital and the Specialist Hospital, both within Sokoto metropolis, Sokoto state, Northwestern Nigeria. Newly diagnosed patients, in-patients and those who declined participation were excluded from the study.

Conditions

Hypertension

Keywords

Treatment adherence; Ambulatory hypertensive patients; Blood pressure; Non-pharmacological measures

Outcome Measures

Primary Outcomes (1)

• Questionnaire with a nine-item adherence scale to assess the level of adherence to medication

  Questionnaire with a nine-item adherence scale was used to assess the level of adherence to medication, while dichotomous Yes/No response option was used to evaluate the level of adherence to the 4-domains of non-pharmacological lifestyle modifications, specifically smoking, alcohol, exercise, and salt-restriction. Using the Statistical Package for Social Sciences version 22 at p \< 0.05 level of significance, descriptive statistics including frequency and percentage was used to summarise the data on these parameters

  5 hours on Thursday clinic days, 16 weeks

Secondary Outcomes (2)

• Perception and belief about hypertension and treatment

  5 hours on Thursday clinic days, 16 weeks

• Data collection form to retrieve the average of two consecutive blood pressure readings (Systolic and Diastolic)

  4 hours on Thursday clinic days, 16 weeks

Interventions

Adherence Education OTHER

Patients were given adherence education to resolve the identified deficits

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Ambulatory hypertensive patients

You may qualify if:

• Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on antihypertensive medications for at least 3-months were enrolled.

You may not qualify if:

• Newly diagnosed patients, in-patients and those who declined participation were excluded from the study

Sponsors & Collaborators

• University of Ibadan: lead

Study Sites (1)

Usmanu Danfodiyo University Teaching Hospital

Sokoto, 840252, Nigeria

Location

MeSH Terms

Conditions

Hypertension; Treatment Adherence and Compliance

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Health Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Medication Therapy Management Research in Communicable and non-communicable

Study Record Dates

• First Submitted: February 28, 2018
• First Posted: March 26, 2018
• Study Start: February 1, 2017
• Primary Completion: May 30, 2017
• Study Completion: May 30, 2017
• Last Updated: March 26, 2018

Record last verified: 2018-03

Locations

NG (1)