Evaluation of BD Glucan in Peritoneal Fluid for the Diagnosis of Fungal Peritonitis

NCT03469401 | Completed

• 1 other identifier: 69HCL17_0775
• Study Type: observational
• Target: 126
• Locations: 1 country
• Sites: 1

Brief Summary

Invasive candidiasis has a high mortality rate, around 40%. Outcome remains tightly linked to the time of treatment administration. Routine microbiological techniques give results too lately to allow prompt antifungal therapy initiation (at least 48 hours). It is important to develop diagnostic tools to initiate antifungal therapy as early as possible. The B D glucan detection, one of the major components of the candida cell wall, can be useful for a early diagnosis. There are several techniques on the market for the detection of glucan. In Europe and America, the most used is Fungitell (Associated of Cape Cod, Inc). There is several studies about the use of such kits for fungemia. A number of studies are reporting evidences of a early diagnosis. But, in medical literature, there isn't study focused on the detection of B D glucan in peritoneal fluid for Candida peritonitis diagnosis.

Conditions

Adult Patient (Over 18 Yr-old) Admitted to the ICU for Acute Peritonitis

Outcome Measures

Primary Outcomes (1)

• Evaluation of sensibility, specificity, negative and positive predictive value of BD glucan in peritoneal fluid for diagnosis of fungal peritonitis, compared with fungal culture

  Evaluation of sensibility, specificity, negative and positive predictive value of BD glucan in peritoneal fluid for diagnosis of fungal peritonitis, compared with fungal culture

  1 year

Study Arms (1)

intervention

Adult patient (over 18 yr-old) admitted to the ICU for acute peritonitis with a peritoneal fl:uid sample obtained via surgery or radiological drainage

Other: Intervention

Interventions

Intervention OTHER

Evaluation of sensibility, specificity, negative and positive predictive value of BD glucan in peritoneal fluid for diagnosis of fungal peritonitis, compared with fungal culture

intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patient (over 18 yr-old) admitted to the ICU for acute peritonitis

You may qualify if:

• Aged ≥ 18 years old
• stay in intensive care unit
• diagnosed with a peritonitis
• peritoneal fluid collected by a surgery or radiology procedure, analysed at bacteriology laboratory of l'institut des agents infectieux, l'hôpital de la Croix Rousse

You may not qualify if:

• Pregnant woman
• Moribund patient

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Centre Hospitalier Lyon Sud

Pierre-Bénite, France

Location

Related Publications (1)

• Nourry E, Wallet F, Darien M, Menotti J, Dupont D, Allaouchiche B, Argaud L, Richard JC, Guichon C, Rimmele T, Bohe J, Thiollere F, Vassal O, Lepape A, Wallon M, Persat F, Friggeri A. Use of 1,3-Beta-D-Glucan concentration in peritoneal fluid for the diagnosis of intra-abdominal Candidiasis in Critically-ill patients. Med Mycol. 2023 Mar 20:myad029. doi: 10.1093/mmy/myad029. Online ahead of print.

  PMID: 36941133 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

peritoneal fluid

MeSH Terms

Interventions

Methods

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Officials

• Florent WALLET, MD

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2018
• First Posted: March 19, 2018
• Study Start: January 18, 2018
• Primary Completion: January 18, 2019
• Study Completion: February 18, 2019
• Last Updated: September 4, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)