Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)
AIR:RRP
1 other identifier
observational
400
1 country
48
Brief Summary
Recurrent Respiratory Papillomatosis (RRP) causes wart-like growths in the airway which can make it difficult to breathe, speak and carry out normal everyday activities. It is a rare condition affecting all ages, but is more common and aggressive in children than in adults, affecting 4 in every 100,000 children. There is no known cure for RRP, but symptoms are checked through regular hospital visits, with multiple therapies or procedures under general anaesthetic needed to remove or shrink the growths which can grow back quickly. The problem is that nobody knows which therapies or procedures work best. Aim: To identify which RRP treatments currently used in National Health Service (NHS) hospitals within the United Kingdom (UK) are the most effective and safest in the short- and long-term. It will also identify which patients respond best to specific treatments, and those who are at higher risk of experiencing a complication after treatment. Method: Collect information from usual patient care and quality of life questionnaire responses in a secure online database. Participation in this study requires patient/parent/guardian consent. This observational study does not require patients to undergo any additional intervention as part of the research.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2018
Longer than P75 for all trials
48 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 26, 2018
CompletedFirst Posted
Study publicly available on registry
March 14, 2018
CompletedStudy Start
First participant enrolled
April 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2022
CompletedJanuary 11, 2022
January 1, 2022
4.4 years
February 26, 2018
January 10, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time interval between surgical interventions
Time between surgical interventions to maintain symptomatic control
Over study duration (53 months)
Secondary Outcomes (14)
RRP surgical intervention - nature
Over study duration (53 months)
RRP surgical intervention - timing
Over study duration (53 months)
RRP adjuvant therapy - nature
Over study duration (53 months)
RRP adjuvant therapy - timing
Over study duration (53 months)
Histology results
Over study duration (53 months)
- +9 more secondary outcomes
Interventions
Removal of lesions via microdebrider
Removal of lesions via forceps
Removal of lesions via carbon dioxide laser
Removal of lesions via KTP laser
Removal of lesions via pulsed dye laser
Removal of lesions via radiofrequency ablation
Removal of lesions via monopolar suction diathermy
Removal of lesions via plasma coagulation
Removal of lesions via other methods
All adjuvant therapies
Eligibility Criteria
Patients with respiratory papillomatosis receiving hospital treatment
You may qualify if:
- patients of any age (no restrictions) diagnosed with (newly diagnosed or existing) and receiving treatment for respiratory papillomatosis
- informed assent/consent of data participation provided by patient/parent/guardian
You may not qualify if:
- patients participating in other studies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (48)
NHS Grampian
Aberdeen, AB25 2ZB, United Kingdom
Betsi Cadwaladr University Health Board,
Bangor, LL57 2PW, United Kingdom
Basildon & Thurrock University Hospitals NHS FT
Basildon, SS165NL, United Kingdom
Belfast Health and Social Care Trust
Belfast, BT2 8BG, United Kingdom
University Hospital Birmingham NHS Foundation Trust
Birmingham, B15 2GW, United Kingdom
Birmingham Women's and Children's NHS Foundation Trust
Birmingham, B4 6NH, United Kingdom
Blackpool Teaching Hospital NHS FT
Blackpool, FY38NR, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust
Bradford, BD9 6RJ, United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Cambridge, CB2 0QQ, United Kingdom
Cardiff and Vale University Local Health Board
Cardiff, CF14 4XW, United Kingdom
North Cumbria Univeristy Hospital NHS Trust
Carlisle, CA27HY, United Kingdom
Hywel Dda University Health Board
Carmarthen, SA31 3BB, United Kingdom
County Durham and Darlington NHS Foundation Trust
Darlington, DL36HX, United Kingdom
University Hospitals of Derby and Burton NHS Foundation Trust
Derby, DE223NE, United Kingdom
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
Doncaster, DN2 5LT, United Kingdom
NHS Tayside
Dundee, DD2 1GZ, United Kingdom
NHS Lothian
Edinburgh, EH16 4TJ, United Kingdom
Frimley Health NHS Foundation Trust
Frimley, GU16 7UJ, United Kingdom
NHS Greater Glasgow & Clyde
Glasgow, G120XH, United Kingdom
London North West University Healthcare NHS Trust
Harrow, HA1 3UJ, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
Alder Hey Children's NHS Foundation Trust
Liverpool, L12 2AP, United Kingdom
Liverpool University Hospitals NHS Foundation Trust
Liverpool, L7 8XP, United Kingdom
Barts Health NHS Trust
London, E1 2ES, United Kingdom
University College London Hospitals NHS Foundation Trust
London, NW1 2PG, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
London, SE1 7EH, United Kingdom
Lewisham and Greenwich NHS Trust
London, SE13 6LH, United Kingdom
St George's University Hospitals NHS Foundation Trust
London, SW17 0QT, United Kingdom
Imperial College Healthcare NHS Trust
London, W2 1NY, United Kingdom
Great Ormond Street Hospital for Children NHS FT
London, WC1N3JH, United Kingdom
Bedfordshire Hospitals NHS Foundation Trust
Luton, LU4 0DZ, United Kingdom
Manchester University Hospital NHS Foundation Trust
Manchester, M13 9WL, United Kingdom
Pennine Acute Hospitals NHS Trust
Manchester, M8 5RB, United Kingdom
Wirral University Teaching Hospitals NHS Foundation Trust
Metropolitan Borough of Wirral, CH49 5PE, United Kingdom
South Tees Hospitals NHS Foundation Trust
Middlesbrough, TS4 3BW, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, NE7 7DN, United Kingdom
Isle of Wight NHS Trust
Newport, PO30 5TG, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, NG51PB, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, OX3 9DU, United Kingdom
University Hospital of Plymouth NHS Trust
Plymouth, PL6 8DH, United Kingdom
Swansea Bay University Health Board
Port Talbot, SA12 7BR, United Kingdom
East Sussex Healthcare NHS Trust
Saint Leonards-on-Sea, TN37 7PT, United Kingdom
Salford Royal NHS Foundation Trust
Salford, M6 8HD, United Kingdom
Sheffield Children's NHS Foundation Trust
Sheffield, S10 2TH, United Kingdom
The Shrewsbury and Telford Hospital NHS Trust
Shrewsbury, SY3 8XQ, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, SO16 6YD, United Kingdom
Stockport NHS Foundation Trust
Stockport, SK2 7JE, United Kingdom
South Tyneside and Sunderland NHS Foundation Trust
Sunderland, SR4 7TP, United Kingdom
Related Publications (1)
Donne AJ, Keltie K, Burn J, Belilios E, Powell S, Cognigni P, Nixon IJ, Bateman N, Kubba H, Judd O, Sims A. Current Practice, Safety and Efficacy of Interventions for Recurrent Respiratory Papillomatosis: Evidence From a UK Registry. Clin Otolaryngol. 2025 Mar;50(2):271-279. doi: 10.1111/coa.14245. Epub 2024 Oct 24.
PMID: 39445512DERIVED
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Adam Donne
Alder Hey Children's NHS Foundation Trust
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 53 Months
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 26, 2018
First Posted
March 14, 2018
Study Start
April 1, 2018
Primary Completion
August 31, 2022
Study Completion
August 31, 2022
Last Updated
January 11, 2022
Record last verified: 2022-01
Data Sharing
- IPD Sharing
- Will not share
Patients will be informed that all data collected will be used for research purposes, no patient identifiable information will be shared with external parties for commercial purposes, patient identifiable information will only be accessible by clinicians at their treating organisation, pseudonymised data will be accessed by study analysts, and that only anonymised high-level aggregate data will be shared with other centres to update participating centres of study progress and data completeness issues. Patients will also be informed that any external researchers requesting data from the registry will be required to submit a formal application form and evidence of appropriate ethical approvals in place for review by the Steering Group. If approval is given, only anonymised data will be shared for the purposes of external research studies.