DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

NCT03462277 | Completed DMC

• 1 other identifier: 2016-39
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.

Conditions

Coronary Heart Disease

Keywords

methylation; hydroxymethylation; atherosclerosis; coronary heart disease

Outcome Measures

Primary Outcomes (1)

• DNA Methylation and Hydroxymethylation Levels

  Collection of blood samples and measuring the samples by PCR and ELISA

  1 month

Study Arms (2)

Control group

Control group was defined as people with negative findings in coronary angiograms.

Coronary Heart Disease group

CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Coronary Heart Disease and Patients without Coronary Heart Disease. All patients underwent carotid ultrasound and coronary angiograms.

You may qualify if:

• Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.

You may not qualify if:

• Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.

Sponsors & Collaborators

• Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

human blood samples, human aortic tissues

MeSH Terms

Conditions

Coronary Disease; Atherosclerosis

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases

Study Officials

• Dongying Zhang, doctor

  First Affiliated Hospital of Chongqing Medical University

  STUDY DIRECTOR

• Dan Jiang

  First Affiliated Hospital of Chongqing Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: March 6, 2018
• First Posted: March 12, 2018
• Study Start: January 1, 2018
• Primary Completion: August 1, 2018
• Study Completion: October 1, 2018
• Last Updated: July 17, 2019

Record last verified: 2019-07

Locations

CN (1)