Personalised Cognitive Remediation Therapy (pCRT)

NCT03461432 | Unknown DMC

• 1 other identifier: 231245
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cognitive deficits have been shown to have negative impact on social functioning and functional goals such as ability to work and perform daily tasks in people with schizophrenia. There is evidence that Cognitive Remediation Therapy, a form of psychological therapy, is effective in improving cognition and functioning but there is still a limited understanding of what influence people's different response to this therapy. A tailored treatment is likely to be more effective because it will adapt to service users' unique characteristics. The investigators are planning a study exploring at the feasibility and acceptability of novel form of Cognitive Remediation Therapy which is personalised (pCRT) to the person individual characteristics. The personalised therapy will consist of task practice using computerized Cognitive Remediation software (i.e. called CIRCuiTS). The knowledge gathered in this work will contribute to develop the next generation of personalised treatment approaches for people with schizophrenia.

Conditions

Schizophrenia Schizoaffective

Keywords

Cognitive Remediation Therapy CRT

Outcome Measures

Primary Outcomes (1)

• Feasibility of intervention (including acceptance rates, drop outs)

  Feasibility estimates of delivering the intervention including acceptance rates, drop outs.

  3 months post baseline assessment

Secondary Outcomes (1)

• Acceptability of intervention (Satisfaction)

  3 months post baseline assessment

Study Arms (1)

Personalised Cognitive Remediation Therapy (pCRT)

EXPERIMENTAL

A case-control study design with pre- and post-therapy assessment, comparing a group of participants with schizophrenia who received standard CRT, with a similar group of participants receiving pCRT.

Behavioral: Cognitive Remediation Therapy

Interventions

Cognitive Remediation Therapy BEHAVIORAL

Cognitive Remediation Therapy (CRT) is a psychological therapy that has been developed with a general immediate focus on improving impaired cognitive domains but ultimately aimed at improving social and functional outcomes.

Personalised Cognitive Remediation Therapy (pCRT)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• a range of 18-65 years
• English speaking or with a good knowledge of the language
• a diagnosis of schizophrenia or schizoaffective disorder according to the DSM- V
• at least one year contact with mental health services,
• a deficit (of at least one standard deviation below the mean) in at least one cognitive domain out of these three cognitive domains: memory, executive function and information processing.

You may not qualify if:

• Planned medication change
• Diagnosis of learning disability
• Presence of cognitive deficits related to organic causes or head injury
• Primary diagnosis of substance dependence

Sponsors & Collaborators

• King's College London: lead

Related Publications (1)

• Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011 May;168(5):472-85. doi: 10.1176/appi.ajp.2010.10060855. Epub 2011 Mar 15.

  PMID: 21406461 RESULT

MeSH Terms

Conditions

Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Central Study Contacts

Benedetta Seccomandi, PhD student

CONTACT

02078485728; benedetta.seccomandi@kcl.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A case-control study design with pre- and post-therapy assessment.

Study Record Dates

• First Submitted: February 15, 2018
• First Posted: March 12, 2018
• Study Start: October 31, 2018
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: August 14, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will not share