Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)

NCT03459456 | Active Not Recruiting

• 1 other identifier: H41632
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 3

Brief Summary

The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically relevant contexts.

Conditions

OCD; Obsessive-Compulsive Disorder

Keywords

OCD; Obsessive-Compulsive Disorder

Outcome Measures

Primary Outcomes (1)

• Change in brain activity

  measured before, during and after PROVOC task, Trier Social Stress Test (TSST) and exposure task

  baseline to Hour 2

Secondary Outcomes (1)

• Change in Heart Rate

  baseline to Hour 2

Study Arms (2)

OCD subjects

Subjects meeting inclusion/exclusion criteria with OCD will be exposed to the following: * Provocation OC task (Provoc) * Trier Social Stress Test (TSST) * Exposure provocation task

Behavioral: Provocation OC task (Provoc); Behavioral: Trier Social Stress Test (TSST); Behavioral: Exposure provocation task

Control subjects

Subjects meeting inclusion/exclusion criteria without OCD (age and gender matched with OCD subjects) will be exposed to the following: * Provocation OC task (Provoc) * Trier Social Stress Test (TSST) * Exposure provocation task

Behavioral: Provocation OC task (Provoc); Behavioral: Trier Social Stress Test (TSST); Behavioral: Exposure provocation task

Interventions

Provocation OC task (Provoc) BEHAVIORAL

used to evoke OC-related distress

Control subjects; OCD subjects

Trier Social Stress Test (TSST) BEHAVIORAL

used to evoke anxiety unrelated to OCD (e.g., performance anxiety)

Control subjects; OCD subjects

Exposure provocation task BEHAVIORAL

used to elicit overt OCD rituals

Control subjects; OCD subjects

Eligibility Criteria

• Age: 21 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The primary source of OCD subjects will be self-referrals generated through BCM Clinicaltrials website, Clinicaltrials.gov, and BCM Psychiatry Clinic. The investigators also anticipate referrals from local area clinicians in addition to affiliate entities.

You may qualify if:

• OCD subjects:
• The subject has a minimum score of ≥16 on the Y-BOCS;
• If applicable, on a stable pharmacologic regimen;
• Sample will be enriched with OCD subjects having contamination obsessions and handwashing compulsions, and scores on items 9 and 10 of the Y-BOCS reflecting difficulty resisting and controlling compulsions;
• Healthy Control Subjects:
• Men and women will be age/gender matched with subjects
• Absence of any psychiatric disorder determined by the MINI\^53 for DSM-5 with the exception of non-impairing specific phobia.
• Low scores on measures of contamination concerns and disgust sensitivity based on Y-BOCS scores below 10 and the Disgust Scale-Revised (total score \<8).

You may not qualify if:

• OCD Subjects:
• Subject has a documented lifetime diagnosis of psychotic disorders such as schizophrenia;
• Alcohol or substance abuse/dependence reported within 6 months, excluding nicotine;
• The subject is deemed at high risk of suicidal behavior or impulsivity. The Beck Depression Inventory\^52 (BDI) will be completed by all subjects and responses reviewed by a clinician.
• Healthy Control Subjects:

Sponsors & Collaborators

• Baylor College of Medicine: lead
• Brown University: collaborator
• University of Pittsburgh: collaborator

Study Sites (3)

University of Pittsburgh

Pittsburgh, Pennsylvania, 15260, United States

Location

Brown University

Providence, Rhode Island, 02912, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Interventions

Psychological Tests

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavioral Disciplines and Activities

Study Officials

• Wayne Goodman, MD

  Baylor College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 1, 2018
• First Posted: March 9, 2018
• Study Start: June 11, 2018
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: August 18, 2025

Record last verified: 2025-08

Locations

US (3)