Nitrate Supplementation and Muscle Blood Flow
Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age
1 other identifier
interventional
10
1 country
1
Brief Summary
The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2017
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 10, 2017
CompletedFirst Submitted
Initial submission to the registry
October 11, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 8, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 8, 2018
CompletedFirst Posted
Study publicly available on registry
March 8, 2018
CompletedJanuary 9, 2019
January 1, 2019
4 months
October 11, 2017
January 8, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound
Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate.
Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits.
Study Arms (2)
Nitrate Rich Beetroot Powder (nitrate)
ACTIVE COMPARATORDietary nitrate in the form of beetroot powder (10g) mixed in water will be administered acutely
Placebo Beetroot Powder
PLACEBO COMPARATORBeetroot powder devoid of nitrate (10g) will be mixed in water and administered acutely
Interventions
Nitrate rich beetroot powder (10g) acutely
Nitrate devoid beetroot powder (10g) acutely
Eligibility Criteria
You may qualify if:
- Healthy older adults 60-80 years of age
You may not qualify if:
- Hypertension,
- Smoking,
- Heart disease,
- Diabetes,
- Body mass index (BMI) ≥ 30 kg/m2,
- Autonomic disorders and other conditions that may alter blood pressure or vascular function
- Medications that might normally alter blood pressure or vascular function.
- Older women taking hormone replacement therapy medications.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical Education Building
Iowa City, Iowa, 52242, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
October 11, 2017
First Posted
March 8, 2018
Study Start
October 10, 2017
Primary Completion
February 8, 2018
Study Completion
February 8, 2018
Last Updated
January 9, 2019
Record last verified: 2019-01