The Patients' Experience After Stem Cell Transplant

NCT03454568 | Completed

• 1 other identifier: 0431-17-EP
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; whether these changes affect day-to-day activities and quality of life and how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory.

Conditions

Stem Cell Transplant Complications

Keywords

Stem Cell Transplant

Outcome Measures

Primary Outcomes (1)

• Assess differences with cognitive function in older patients undergoing allogeneic or autologous stem cell transplant at 4 timepoints.

  Cognition will be measured using a neuropsychological battery.

  Before transplant; Post Transplant at 100 days, 6 months, and 12 months

Secondary Outcomes (3)

• Assess quality of life of of older patients undergoing allogeneic and autologous transplant at 4 timepoints.

  Before transplant; Post Transplant at 100 days, 6 months, and 12 months

• Assess activity engagement of older patients undergoing allogeneic and autologous transplant at 4 timepoints.

  Before transplant; Post Transplant at 100 days, 6 months, and 12 months

• Describe genetic variations in genes potentially involved in cognitive function and cancer treatment.

  1 time collection: Before transplant

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population is being recruited from the Fred \& Pamela Buffett Cancer Center at the University of Nebraska Medical Center.

You may qualify if:

• Between the ages of 60-85
• Diagnosed with a hematological malignancy
• Is considering an autologous or allogeneic stem cell transplant OR has undergone stem cell transplant in the past 12 months and seen by the PI for pre-transplant evaluation.
• Is able to read, write, speak, and understand English

You may not qualify if:

• As per self report or medical record, history of central nervous system involvement and/or history of cranial irradiation or intrathecal chemotherapy except for patients with history of prophylactic intrathecal chemotherapy.
• As per self report or medical record, history of stroke, head injury, neurosurgery, seizure disorder, or demyelinating disorder.
• As per self report or medical record, history of substance use disorder.
• As per self report or in the judgement of the consenting professional, uncorrected vision loss.
• As per self report or medical record, primary psychiatric disorder necessitating inpatient treatment in the last 12 months.
• As per self report or medical record, history of allogeneic and or autologous stem cell transplant.

Sponsors & Collaborators

• University of Nebraska: lead

Study Sites (1)

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

A saliva sample will be obtained.

Study Officials

• Thuy Koll, MD

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 19, 2018
• First Posted: March 6, 2018
• Study Start: September 1, 2017
• Primary Completion: November 11, 2022
• Study Completion: November 11, 2022
• Last Updated: January 8, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)