NCT03448380

Brief Summary

This is a prospective, multi-center, non-randomized, single-arm, post-approval study of the FreeStyle Libre Flash Glucose Monitoring System intended to characterize the safety of the Libre Flash Glucose Monitoring System when used in people with diabetes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
935

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2018

Typical duration for all trials

Geographic Reach
1 country

10 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 22, 2018

Completed
5 days until next milestone

Study Start

First participant enrolled

February 27, 2018

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 28, 2018

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2021

Completed
Last Updated

June 16, 2021

Status Verified

June 1, 2021

Enrollment Period

3.1 years

First QC Date

February 22, 2018

Last Update Submit

June 14, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Safety of the FreeStyle Libre Flash Glucose Monitoring System

    The study is designed to characterize the safety of the FreeStyle Libre Flash Glucose Monitoring System when used in the intended study population.

    Approximately one year per subject.

Study Arms (1)

SMBG and FreeStyle Libre

During the intervention phase, subjects will use FreeStyle Libre Flash Glucose Monitoring System for 6 months to managed their diabetes.

Device: FreeStyle Libre Flash Glucose Monitoring System

Interventions

Subjects will utilize capillary SMBG for managing diabetes for 6 months (control phase) followed by diabetes management using FreeStyle Libre for 6 months (intervention phase).

SMBG and FreeStyle Libre

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult subjects aged 18 years and older with type 1 or type 2 diabetes, who require daily blood glucose monitoring to manage their diabetes. At least 20% of the study population will be age 30 or below and 15% will be age 65 or older.

You may qualify if:

  • Subject must be at least 18 years of age.
  • Subject must have a diagnosis of type 1 or type 2 diabetes mellitus.
  • Subject is currently using SMBG for managing their diabetes.
  • Subject must be able to read and understand English
  • In the investigator's opinion, the subject must be able to follow the instructions provided to him/her by the study site and perform all study tasks as specified by the protocol.
  • Subject must have access to an internet connected computer for uploading data from the blood glucose meter and FreeStyle Libre system.
  • Subject must be willing and able to provide written signed and dated informed consent.

You may not qualify if:

  • Subject is a member of the Site Staff.
  • Subject is currently using or has previously used a continuous glucose monitoring system for managing their diabetes
  • Subject has known allergy to medical grade adhesive or isopropyl alcohol used to disinfect skin.
  • Subject is pregnant or is attempting to become pregnant at the time of enrollment.
  • Subject is on dialysis at the time of enrollment.
  • Subject has concomitant medical condition which, in the opinion of the investigator, could interfere with the study or present a risk to the safety or welfare of the subject or study staff.
  • Subject currently is participating in another clinical trial.
  • Subject is unsuitable for participation due to any other cause as determined by the Investigator.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (10)

Sansum Diabetes Research Institute

Santa Barbara, California, 93105, United States

Location

Baptist Diabetes Associates, P.A

Miami, Florida, 33156, United States

Location

Metabolic Research Institute

West Palm Beach, Florida, 33401, United States

Location

Rocky Mountain Diabetes & Osteoporosis Center

Idaho Falls, Idaho, 83404, United States

Location

Iowa Diabetes & Endocrinology Research Center

Des Moines, Iowa, 50265, United States

Location

MassResearch, LLC

Waltham, Massachusetts, 02453, United States

Location

Henry Ford Medical Center

Detroit, Michigan, 48202, United States

Location

Albuquerque Neuroscience Inc.

Albuquerque, New Mexico, 87109, United States

Location

Texas Diabetes & Endocrinology

Round Rock, Texas, 78681, United States

Location

Clinical Trials of Texas

San Antonio, Texas, 78229, United States

Location

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Shridhara A Karinka, PhD

    Abbott Diabetes Care Inc

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 22, 2018

First Posted

February 28, 2018

Study Start

February 27, 2018

Primary Completion

March 30, 2021

Study Completion

March 30, 2021

Last Updated

June 16, 2021

Record last verified: 2021-06

Data Sharing

IPD Sharing
Will not share

Locations