The Role of Consumption and Anticipation in Dopamine Release to Food Reward

NCT03447561 | Unknown

• 1 other identifier: S60362-h
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to disentangle the relative contribution of the anticipatory (food images) versus consummatory (food administration) component of dopamine release to food reward, by performing simultaneous Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanning. Additionally, this study aims to assess the relationship of the dopamine release with (changes in) metabolic hormone levels.

Conditions

Healthy; Food Reward

Keywords

Dopamine; Food; Reward; Anticipatory; Consummatory; Positron Emission Tomography; Magnetic Resonance; Metabolic hormones

Outcome Measures

Primary Outcomes (1)

• Dopamine release to combined vs consummatory food reward

  Changes in \[18F\]-Fallypride binding potential (reflecting dopamine release) in the food reward condition

  Continuously over 225 minutes after onset scanning

Secondary Outcomes (3)

• Composite measure of Metabolic hormone levels

  5 minutes before onset scanning and 45, 105, 165, 180, 195, 210 and 225 minutes after onset scanning

• Amount of milkshake consumed during drink test

  230 minutes after onset of scanning (immediately following end of scanning)

• Temperament and Character Inventory questionnaire

  baseline, dopamine release measured 225 minutes following onset scanning

Other Outcomes (1)

• Ratings of appetite-related sensations composite

  5 minutes before onset of scanning and several time-points up to 225 minutes after onset of scanning

Study Arms (2)

Anticipatory + consummatory food reward

EXPERIMENTAL

PET-MR scan session with a combination of anticipatory (viewing high-calorie food images) and consummatory food reward (drinking sips of chocolate milkshake). This scan session will consist of four blocks with a duration of 45 minutes each and 15 minute breaks in between. The first three blocks represent the 'control condition' (viewing neutral images and drinking sips of water) and the fourth block the 'food reward condition' (viewing high-calorie food images and drinking sips of chocolate milkshake).

Behavioral: Anticipatory + consummatory food reward

Consummatory food reward

EXPERIMENTAL

PET-MR scan session with purely consummatory food reward (drinking sips of chocolate milkshake). This scan session will consist of four blocks with a duration of 45 minutes each and 15 minute breaks in between. The first three blocks represent the 'control condition' (drinking sips of water) and the fourth block the 'food reward condition' (drinking sips of chocolate milkshake).

Behavioral: Consummatory food reward

Interventions

Anticipatory + consummatory food reward BEHAVIORAL

Exposure to a combination of anticipatory (viewing high-calorie food images) and consummatory food reward (drinking sips of chocolate milkshake).

Anticipatory + consummatory food reward

Consummatory food reward BEHAVIORAL

Exposure to consummatory food reward (drinking sips of chocolate milkshake).

Consummatory food reward

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy females (on hormonal contraception)
• Dutch-speaking
• Right-handed
• Stable body weight with Body Mass Index (BMI) of 18.5 - 25 kg/m\^2

You may not qualify if:

• Medical, neurological or psychiatric disorders
• Use of psychotropic medication in past 6 months
• Use of cannabis or other drugs of abuse in past 12 months
• Lactose-intolerance or food allergies
• Vegetarian diet
• Smoking
• Consumption of more than 7 alcoholic units per week
• Exposure to a significant amount of ionizing radiation in past 12 months
• Claustrophobia
• Contra-indications for Magnetic Resonance Imaging
• Pregnancy

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

Universitaire ziekenhuizen Leuven

Leuven, 3000, Belgium

RECRUITING

Study Officials

• Lukas Van Oudenhove, Prof. dr.

  Universitaire Ziekenhuizen KU Leuven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lukas Van Oudenhove, Prof. dr.

CONTACT

003216330147; lukas.vanoudenhove@kuleuven.be

Danielle Jongen, Msc

CONTACT

003216376200; danielle.jongen@kuleuven.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: All participants will receive one PETMR scan session with the combination of anticipatory (viewing high-calorie food images) and consummatory reward (drinking sips of chocolate milkshake), and one PETMR scan session with purely consummatory reward, in a randomized and counterbalanced order.

Study Record Dates

• First Submitted: February 8, 2018
• First Posted: February 27, 2018
• Study Start: February 8, 2018
• Primary Completion: June 1, 2019
• Study Completion: June 1, 2019
• Last Updated: February 27, 2018

Record last verified: 2018-02

Locations

BE (1)