Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

NCT03447002 | Completed

• 1 other identifier: ErciyesU
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Conditions

Premature Ventricular Contraction

Keywords

premature; pvc

Outcome Measures

Primary Outcomes (1)

• metanephrine and normetanephrine levels

  metanephrine and normetanephrine levels asociated premature ventricular complex frequents

  about 10 months

Interventions

24 hours urine levels metanephrine and normetanephrine DIAGNOSTIC_TEST

24 hours rhythm recording and 24 hours urine measurement

Also known as: rhythm recording

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with % 5 or higher frequents premature ventricular complex in 24 hours rhythm recording will be taken our study.

You may qualify if:

• PVC's rate is more than % 5 in 24 hours rhythm recording

You may not qualify if:

• ischemic heart disease
• hyperthyroidism
• patients with low ejection fraction

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes university Yilmaz- mehmet öztaşkın heart hospital

Kayseri, Turkey (Türkiye)

Location

Related Publications (3)

• Im SI, Park KM, Park SJ, Kim JS, On YK. New electrocardiographic criteria for predicting successful ablation of premature ventricular contractions from the right coronary cusp. Int J Cardiol. 2016 Dec 1;224:199-205. doi: 10.1016/j.ijcard.2016.09.029. Epub 2016 Sep 16.

  PMID: 27657474 BACKGROUND

• Bradfield JS, Homsi M, Shivkumar K, Miller JM. Coupling interval variability differentiates ventricular ectopic complexes arising in the aortic sinus of valsalva and great cardiac vein from other sources: mechanistic and arrhythmic risk implications. J Am Coll Cardiol. 2014 May 27;63(20):2151-2158. doi: 10.1016/j.jacc.2014.02.551. Epub 2014 Mar 19.

  PMID: 24657687 BACKGROUND

• Cesur B, Elcik D, Cetinkaya Z, Kelesoglu S, Karabiyik U, Inanc MT, Kalay N, Ergin A, Topsakal R. Association between excess catecholamine synthesis and polymorphic premature ventricular contraction. J Electrocardiol. 2024 Jan-Feb;82:59-63. doi: 10.1016/j.jelectrocard.2023.11.010. Epub 2023 Nov 26.

  PMID: 38035655 DERIVED

MeSH Terms

Conditions

Ventricular Premature Complexes; Premature Birth

Condition Hierarchy (Ancestors)

Cardiac Complexes, Premature; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: burak cesur

Study Record Dates

• First Submitted: February 19, 2018
• First Posted: February 27, 2018
• Study Start: February 15, 2018
• Primary Completion: September 30, 2019
• Study Completion: September 30, 2019
• Last Updated: November 14, 2019

Record last verified: 2019-11

Locations

TU (1)