Serum 25(OH) Vitamin D and Total Serum Immunoglobulin E Levels in Patients With Pityriasis Alba

NCT03443765 | Active Not Recruiting

• 1 other identifier: Project #002
• Study Type: observational
• Target: 280
• Locations: 1 country
• Sites: 1

Brief Summary

Pityriasis alba (PA) is a common, benign skin disorder occurring predominantly in children and adolescents. It is characterized by ill-defined hypopigmented macules and patches, round or oval in shape. They are most commonly located on the face (especially the cheeks), arms, and upper trunk; and they are more noticeable in people with darker skin types. Sun exposure accentuates the lesions. Patients and their parents are often anxious about the cosmetic appearance of the lesions. PA is not seasonal, although peeling may be worse in the winter (as a result of dry air in homes) and lesions may be more obvious in the spring and summer (as a result of sun exposure and darkening of the surrounding skin).No specific cause of PA has been identified. It is not contagious, and no infectious etiology has been reported. It is most common in individuals with a history of atopy, although it may occur in nonatopic individuals. In the present study, we will investigate the role of serum vitamin D levels and serum total IgE levels with development and course of PA. Plasma levels of 25(OH) vitamin D and Total serum immunoglobulin E will be determined by using ELISA technique.

Conditions

Pityriasis Alba

Outcome Measures

Primary Outcomes (2)

• Serum 25(OH) vitamin D levels in the patients with pityriasis alba

  In this study we expect to determine a role of Vitamin D in the development and course of pityriasis alba

  up to 24 months

• Total serum immunoglobulin E levels in the patients with pityriasis alba

  In this study we expect to determine a role of immunoglobulin E in the development and course of pityriasis alba

  up to 24 months

Study Arms (2)

Patients with Pityriasis alba

Diagnostic Test: Detection of Plasma levels of 25(OH) vitamin D by ELISA technique; Diagnostic Test: Detection of Total serum immunoglobulin E by ELISA technique

Healthy participants (control group)

Diagnostic Test: Detection of Plasma levels of 25(OH) vitamin D by ELISA technique; Diagnostic Test: Detection of Total serum immunoglobulin E by ELISA technique

Interventions

Detection of Plasma levels of 25(OH) vitamin D by ELISA technique DIAGNOSTIC_TEST

Five milliliters of peripheral venous blood sample will be taken (after 8-12 hours of fasting) from each participant and will be collected into HumaTube Serum Gel - C/A for ELISA. Serum will be appropriately obtained and stored at -20°C maximum of 30 days. Plasma levels of 25(OH) vitamin D will be detected by enzyme-linked immunosorbent assay (ELISA) technique.

Healthy participants (control group); Patients with Pityriasis alba

Detection of Total serum immunoglobulin E by ELISA technique DIAGNOSTIC_TEST

Five milliliters of peripheral venous blood sample will be taken (after 8-12 hours of fasting) from each participant and will be collected into HumaTube Serum Gel - C/A for ELISA. Serum will be appropriately obtained and stored at -20°C maximum of 30 days. Total serum immunoglobulin E will be detected by enzyme-linked immunosorbent assay (ELISA) technique.

Healthy participants (control group); Patients with Pityriasis alba

Eligibility Criteria

• Age: 5 Years - 14 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The prospective cohort study will be conducted on the basis of Research Institute of Epidemiology, Microbiology and Infectious Disease, Ministry of Public Health of the Republic of Uzbekistan. All participants will be residents of Uzbekistan. Diagnosis of pityriasis alba will be based on the results of clinical examination.

You may qualify if:

• Patients with Pityriasis alba
• Healthy individuals (control group)

You may not qualify if:

• chronic and acute infectious diseases;
• endocrine diseases;
• congenital diseases;
• allergic dermatitis;
• bronchial asthma;
• allergic rhinitis and/or conjunctivitis;
• other skin disorders;
• history of using vitamin D supplements within three months ago, or use of any medication influencing endocrine parameters.

Sponsors & Collaborators

• Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan: lead

Study Sites (1)

Research institute of epidemiology, microbiology and infectious diseases

Tashkent, Uchtepa, 100133, Uzbekistan

Location

Related Publications (1)

• Toychiev A, Mirzoeva M, Davis N, Islamova J, Osipova S. Pityriasis alba: Possible associations with intestinal helminths and pathogenic protozoa. Int J Clin Pract. 2020 Feb;74(2):e13441. doi: 10.1111/ijcp.13441. Epub 2019 Oct 30.

  PMID: 31633268 BACKGROUND

MeSH Terms

Conditions

Dandruff

Condition Hierarchy (Ancestors)

Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Scalp Dermatoses

Study Officials

• Svetlana Osipova, MD, PhD, DS

  research institute of epidemiology, microbiology and infectious diseases

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 16, 2018
• First Posted: February 23, 2018
• Study Start: May 1, 2017
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: April 4, 2025

Record last verified: 2025-04

Locations

UZ (1)