Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome
The 15-year Impact of Severe Acute Respiratory Syndrome on Organ Functions, Exercise Capacity, and Quality of Life in Survivors.
1 other identifier
observational
150
1 country
1
Brief Summary
SARS-CoV has caused severe epidemic respiratory disease in human populations. By July 2003, a total of 8,096 probable cases of SARS had been reported including 774 deaths in 27 countries, around one-third of which were health care workers (HCWs). Previous studies have been reported about long-term impacts of SARS infection, including lung function deficiency, steroid-induced osteonecrosis, reduced exercise capacity, and impairment in health-related quality of life (HRQoL). HCWs, especially nurses, have been reported to experience greater psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). But the very complex impacts of this fatal infection on HCWs have not been fully elucidated. It is thus important to follow these occupational patients to detect and manage multi-organ sequelae and functional impairment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 25, 2018
CompletedFirst Submitted
Initial submission to the registry
February 4, 2018
CompletedFirst Posted
Study publicly available on registry
February 22, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2018
CompletedFebruary 26, 2018
February 1, 2018
5 months
February 4, 2018
February 22, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
All-cause disability
Disabilities arising from physical injuries and/or mental stresses
Evaluations would be finished within 90 days after enrollment.
Secondary Outcomes (2)
Cardiopulmonary function
Evaluations would be finished within 90 days after enrollment.
Life Life quaities mental distress
Evaluations would be finished within 90 days after enrollment.
Study Arms (2)
SARS survivors
First-line HCWs infected during the SRAS-CoV pandemic in Peking University People's Hospital, China. Diagnose was further confirmed by SARS-CoV seropositive results.
Controls
1. Coworkers of the infected HCWs, who also exposed to SARS patients or specimens. Infection was further excluded by SARS-CoV seronegative results. 2. Healthy controls matched for age, sex and disease condition, but without exposures to SARS virus.
Eligibility Criteria
Health care workers who were working at Peking University People's Hospital during the SARS epidemic in 2002-2003 will be enrolled.
You may qualify if:
- Health care workers who were working at Peking University People's Hospital during the SARS epidemic in 2002-2003
You may not qualify if:
- Refusal to continue the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking University People's Hospital
Beijing, Beijing Municipality, 100044, China
Related Publications (1)
Li J, Zheng Y, Zhao L, Yue Z, Pan F, Chen Y, Yu B, Chen Y, Zhao G, Zhou Y, Gao Z. Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years. BMC Infect Dis. 2021 Nov 24;21(1):1183. doi: 10.1186/s12879-021-06881-3.
PMID: 34819019DERIVED
Biospecimen
Peripheral Blood Mononuclear Cells would be extracted from participators.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Baoguo Jiang, Dr
Peking University People's Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head of Respiartory and Critical Care Medicine
Study Record Dates
First Submitted
February 4, 2018
First Posted
February 22, 2018
Study Start
January 25, 2018
Primary Completion
July 1, 2018
Study Completion
December 1, 2018
Last Updated
February 26, 2018
Record last verified: 2018-02