Assessment of Skeletal Muscle Dysfunction in Patient With Idiopathic Pulmonary Fibrosis

NCT03440489 | Unknown

• 1 other identifier: SMD
• Study Type: interventional
• Target: 1
• Locations: 0 countries
• Sites: N/A

Brief Summary

Interstitial lung disease includes a heterogeneous group of chronic lung conditions that is characterized by exertional dyspnoea and poor health related quality of life . includes idiopathic pulmonary fibrosis of unknown cause And another groups are caused by occupational, inorganic or organic exposure, drug- induced toxicities, or are secondaries to connective tissue disease The clinical course and outcome of interstitial lung diseases are highly variable between different sub types, but survival after diagnosis of idiopathic pulmonary fibrosis is only 2.5 to 5 years is a progressive and fibrosing lung disease that is characterized by architectural distortion of the lung parenchyma and is progressive, with a dismal prognosis Also patient with idiopathic pulmonary fibrosis generally demonstrate greater abnormalities of exercise induced gas exchange than those with other forms of Interstitial lung disease

Conditions

Interstitial Lung Disease; Skeletal Muscle Dysfunction

Outcome Measures

Primary Outcomes (1)

• assess skeletal muscle dysfunction in interstitial lung diseased patients by 30 seconds chair stand test

  30 seconds chair stand test

  30 seconds

Study Arms (1)

six-minute walking test

OTHER

physical performance of the muscle: measured by Gait speed test, Timed up and go test, six-minute walking test , 30 seconds chair stand test

Diagnostic Test: Six-minute walking test; Diagnostic Test: 30 seconds chair stand test

Interventions

Six-minute walking test DIAGNOSTIC_TEST

physical performance of the muscle measured by these tests

Also known as: Gait speed test, Timed up and go test

six-minute walking test

30 seconds chair stand test DIAGNOSTIC_TEST

physical performance of the muscle measured by these tests

six-minute walking test

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All patient who will be presented to assuit chest department and diagnosed as IPF.

You may not qualify if:

• IPF patient with malignant tumors. 2-Comorbid end stage renal, cardiac or hepatic patient. 3-patient who refused to participate in the study

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Collard HR, King TE Jr, Bartelson BB, Vourlekis JS, Schwarz MI, Brown KK. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003 Sep 1;168(5):538-42. doi: 10.1164/rccm.200211-1311OC. Epub 2003 May 28.

  PMID: 12773325 BACKGROUND

• Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU, Behr J, Bouros D, Brown KK, Colby TV, Collard HR, Cordeiro CR, Cottin V, Crestani B, Drent M, Dudden RF, Egan J, Flaherty K, Hogaboam C, Inoue Y, Johkoh T, Kim DS, Kitaichi M, Loyd J, Martinez FJ, Myers J, Protzko S, Raghu G, Richeldi L, Sverzellati N, Swigris J, Valeyre D; ATS/ERS Committee on Idiopathic Interstitial Pneumonias. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48. doi: 10.1164/rccm.201308-1483ST.

  PMID: 24032382 BACKGROUND

MeSH Terms

Conditions

Lung Diseases, Interstitial

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Mohamed Abd El-ghany

  Assiut University

  STUDY CHAIR

• Atef el karn

  Assiut University

  STUDY CHAIR

• Sahar Farghaly yuessif

  Assiut University

  STUDY CHAIR

Central Study Contacts

seham abd elmouty

CONTACT

01016887257; Sehamabdelmouty90@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Model Details: skeletal muscle dysfunction in patient with idiopathic pulmonary fibrosis six minute walking test

Study Record Dates

• First Submitted: February 9, 2018
• First Posted: February 22, 2018
• Study Start: July 1, 2018
• Primary Completion: May 1, 2020
• Study Completion: July 1, 2020
• Last Updated: February 22, 2018

Record last verified: 2018-02