Trials Sponsors Conditions Drugs Pricing

Conditions

Cardiovascular Primary Prevention Strategy

Outcome Measures

Primary Outcomes (1)

MACE
Composite of all-cause mortality, myocardial infarction, stroke, and revascularization (coronary, carotid, and peripheral).
5 years

Study Arms (2)

Proactive Current National Guidelines Group

ACTIVE COMPARATOR

Standard Interventional Control Group. Will receive treatment recommendation according to the current National guidelines for statin initiation and follow-up.

Other: Standard Treatment

Proactive CAC Group

EXPERIMENTAL

Investigational Interventional Group. Will undergo coronary artery calcium screening and will receive statin recommendation based on the cardiovascular risk algorithm.

Combination Product: Coronary Artery Calcium Screening and Statin Treatment

Interventions

Coronary Artery Calcium Screening and Statin TreatmentCombination product

Will undergo coronary artery calcium screening and will receive statin treatment based on the cardiovascular risk algorithm.

Proactive CAC Group

Standard TreatmentOther

Patients will be managed following the AHA/ACC guidelines for statin initiation and follow-up.

Proactive Current National Guidelines Group

Eligibility Criteria

Age50 Years - 80 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Male subjects 50 to 80 years of age or female subjects 60 to 80 years of age, of any ethnic origin
Ability to understand and provide agreement to study participation, which must be obtained prior to initiation of any study procedures

Sponsors & Collaborators

Intermountain Health Care, Inc.
Otherlead

Study Sites (1)

Intermountain Medical Center and Intermountain Clinics

Murray, Utah, 84143, United States

Related Publications (2)

Anderson JL, May HT, Winslow T, Le VT, Iverson L, Bair TL, Knowlton KU, Muhlestein JB. CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics. Am Heart J. 2026 Sep;299:107473. doi: 10.1016/j.ahj.2026.107473. Epub 2026 May 7.
PMID: 42106092DERIVED
Muhlestein JB, Knowlton KU, Le VT, Lappe DL, May HT, Min DB, Johnson KM, Cripps ST, Schwab LH, Braun SB, Bair TL, Anderson JL. Coronary Artery Calcium Versus Pooled Cohort Equations Score for Primary Prevention Guidance: Randomized Feasibility Trial. JACC Cardiovasc Imaging. 2022 May;15(5):843-855. doi: 10.1016/j.jcmg.2021.11.006. Epub 2021 Dec 15.
PMID: 34922872DERIVED

Study Officials

Joseph B Muhlestein, MD
Intermountain Health Care, Inc.
PRINCIPAL INVESTIGATOR

Enrollment

5,765 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: NONE
Purpose: PREVENTION
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

February 14, 2018

First Posted

February 20, 2018

Study Start

March 26, 2018

Actual (reported)

Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

Proactive Current National Guidelines Group

Proactive CAC Group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

Proactive Current National Guidelines Group

Proactive CAC Group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations