NCT03435965

Brief Summary

Preterm premature rupture of the membranes (PPROM) is responsible for one-third of all preterm births. Optimum treatment relies on accurate diagnosis and gestational age. The diagnosis of PPROM is made by a combination of examination, patient history and some simple tests.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2018

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 10, 2018

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 19, 2018

Completed
9 months until next milestone

Study Start

First participant enrolled

November 15, 2018

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 15, 2019

Completed
17 days until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2019

Completed
Last Updated

August 6, 2019

Status Verified

August 1, 2019

Enrollment Period

11 months

First QC Date

February 10, 2018

Last Update Submit

August 4, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • number of participants who was diagnosed with leakage of liqour by AmnioQuickDuo+

    the accuracy of amnioQuick to diagnose PROM

    within a week

Study Arms (3)

PPROM from 20- less than 28 weeks

pregnant ladies with PROM from 20 - 28 weeks

Diagnostic Test: AmnioQuickDuo+

PROM from more than 28 weeks - less than 37 weeks

pregnant ladies with PROM from more than 28- less than37 weeks

Diagnostic Test: AmnioQuickDuo+

control group pregnant ladies in labour after 37 weeks

control group pregnant ladies in labour after 37 weeks with rupture of membrane in labour or in cs

Diagnostic Test: AmnioQuickDuo+

Interventions

AmnioQuickDuo+DIAGNOSTIC_TEST

AmnioQuickDuo+ kit for detection of PROM

PPROM from 20- less than 28 weeksPROM from more than 28 weeks - less than 37 weekscontrol group pregnant ladies in labour after 37 weeks

Eligibility Criteria

Age18 Years - 40 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility Detailspregnant ladies with PROM
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

\- pregnant ladies with PROM from 20- 37 weeks came to the hospital to confirm PROM

You may qualify if:

  • pregnant ladies with PROM from 20- 37 weeks

You may not qualify if:

  • Gestational Age \>37 wks Non reassuring CTG Signs of chorioamnonitis ( Fever , maternal or fetal tachycardia , Foul cervical discharge , uterine tenderness or high TLC ) Antepartum hemorrhage

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Kasralainy Hospital

Cairo, Egypt

RECRUITING

Algazeerah

Giza, Egypt

RECRUITING

MeSH Terms

Conditions

Fetal Membranes, Premature Rupture

Condition Hierarchy (Ancestors)

Obstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Study Officials

  • Mahmoud Alalfy

    Algazeerah hospital -Location (Giza -Egypt ) and National Research centre egypt

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Target Duration
3 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Researcher , National Research centre and Specialist of Obstetrics and Gynecology in Aljazeerah hospital

Study Record Dates

First Submitted

February 10, 2018

First Posted

February 19, 2018

Study Start

November 15, 2018

Primary Completion

October 15, 2019

Study Completion

November 1, 2019

Last Updated

August 6, 2019

Record last verified: 2019-08

Data Sharing

IPD Sharing
Will not share

the data will be shared after finishing the research

Locations