Maternal Adversity, Vulnerability and Neurodevelopment

NCT03434457 | Completed Results DMC

• 1 other identifier: DouglasMHU
• Study Type: observational
• Target: 630
• Locations: 1 country
• Sites: 1

Brief Summary

Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads. The main objective of MAVAN project is to examine the pre- and postnatal influences, and their interaction, in determining individual differences in children development. The MAVAN project is designed to examine the consequences of fetal adversity as a function of the quality of the postnatal environment, focusing on mother-infant interactions.

Conditions

Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse); Infant Development; Infant Behavior

Keywords

Fetal growth retardation; Early adversity; Depressive Symptoms

Outcome Measures

Primary Outcomes (17)

• Child's Cognitive Development Measured Using the Bayley Scales of Infant Development II.

  Assessment of child development was done using the cognitive, motor and mental scales of the Bayley Scales of Infant Development II.

  At 6, 12, 18 and 36 months

• Child Temperament Evaluated Using the Infant Behaviour Questionnaire.

  Child temperament was evaluated using the Infant Behaviour questionnaire (IBQ). The items represent 14 scales but factor analysis reveals three primary factors: a) impulsivity, b) negative affectivity and c) effortful control.

  3 and 6 months

• Changes in Child Temperament Evaluated Using the Early Childhood Behaviour Questionnaire.

  Assessment of child's temperament was done with the Early Childhood Behaviour questionnaire, the toddler version of the IBQ. It is comprised of 201 items grouped in 18 subscales and is based on a 7-point Likert scale ranging from "never" to "always". The questionnaire yields 18 sub-scores: activity level/energy, attentional focusing, attentional shifting, cuddliness, fear, frustration, high-intensity pleasure, impulsivity, inhibitory control, low-intensity pleasure, motor activation, perceptual sensitivity, positive anticipation, sadness, shyness, sociability, and soothability.

  18 and 36 months

• Changes in Socio-emotional Development Measured Using the Infant Toddler Socio-emotional Assessment Questionnaire.

  Socio-emotional development was measured using the Infant Toddler Socio-emotional Assessment questionnaire (ITSEA). It consists of 140 items to evaluate four independent behavioral domains: 1) externalizing, (e.g., high-activity, aggression, defiance, and negative emotional reactivity); 2) internalizing, (e.g., mood regulation problems, social withdrawal and extreme inhibition/shyness); 3) dysregulation (e.g., sleep and eating problems, mood regulation); and 4) maladaptation (e.g., repetitive and stereotypic behaviors). Items are rated on a 3-point scale.

  18 and 24 months

• Changes in Child's Behaviour Problems Measured With the Child Behaviour Checklist.

  Child's behaviour was evaluated using the Child Behaviour Checklist (CBCL). The CBCL is a well-validated screen for childhood psychopathology. This parent-rated questionnaire contains 100 items divided in 2 broad scales : Internalizing problems includes : Withdrawn, Somatic Complaints, and Anxious/Depressed subscales. Externalizing problems : including Rule-Breaking Behavior and Aggressive subscales. Total problems score : is the sum of the scores of all the problem items.

  48 and 60 months

• Changes in Child's School Readiness Measured With the School Readiness Test Battery.

  School and academic readiness were assessed using the School readiness test battery, including the Lollipop test, Number knowledge and Peabody Picture Vocabulary test. The NKT measures the development of number concepts. This test measures the mastery of a series of concepts required for learning math and comprises 5 levels. The Lollipop includes 52 questions, divided in 4 knowledge subtests: (1) colours and forms, (2) spatial relationships, (3) numbers and (4) letters. It is a good predictor of reading and math achievement up to 4th grade. The PPVT is a receptive vocabulary test that measures the extent of vocabulary a child can understand. A child is asked to identify a spoken word on an array of four pictures, only one of which is correct.

  48 and 60 months

• Evaluation or Child's Cognitive Development Using the Developmental Neuropsychological Assessment.

  Child's cognitive development was assessed using the sensory-motor and visuo-spatial processing subscales of the Developmental Neuropsychological Assessment (NEPSY).

  48 months

• Evaluation of Child's Cognitive Development Using the Weschler Preschool and Primary Scale of Intelligence.

  Child's cognitive development was assessed using the vocabulary and the bloc design subscales of the Weschler Preschool Primary Scale of Intelligence (WPPSI).

  48 months

• Changes in Child's Hyperactivity Problems Measured With the Conner's.

  The Conner's was designed to be completed by parents and teachers to assist in evaluating children for attention-deficit/hyperactivity disorder (ADHD). The parents' short version contains 27 items and the teachers' short version has 28. The teacher version is similar but lacks the psychosomatic scale contained on the parent version. The Conner's is validated and the standard for informant-administered ADHD assessment both in clinical and research settings. Oppositional, cognitive problems/inattention, hyperactivity subscales.

  60 and 72 months

• Child's Fears Assessed With the Koala Fear Questionnaire.

  The Koala Fear Questionnaire (KFQ) is a standardized self-report scale for assessing fears and fearfulness in children aged between 4 and 12 years. This scale consists of 31 potentially fear-provoking stimuli and situations that are all illustrated with pictures. Children rate the intensity of their fear of these stimuli by using a visual scale depicting Koala bears expressing various degrees of fear ( no fear, some fear, a lot of fear ).

  60 months

• Changes in Child's Emotional and Behaviour Problems Measured With the Strength and Difficulty Questionnaire.

  The Strengths and Difficulties Questionnaire (SDQ) is a brief screening for child emotional and behavioural problems. It is based on 25 items on psychological attributes. 1. emotional symptoms (5 items) 2. conduct problems (5 items) 3. hyperactivity/inattention (5 items) 4. peer relationship problems (5 items) 5. prosocial behaviour (5 items) Number 1) to 4) added together to generate a total difficulties score.

  60 and 72 months

• Child's Behavioural Inhibition and Behavioural Activation Were Measured Using the Behavioural Inhibition System (BIS) and the Behavioural Approach System (BAS)

  The BIS/BAS was designed to assess dispositional sensitivity to the behavioral inhibition system (BIS) and the behavioral activation or behavioral approach system (BAS). Questions 20 items using 4 point scales (1 = strongly disagree to 4 = strongly agree). 2 subscales: Behavioral Inhibition System (BIS) 7 items about anticipation of punishment Behavioral Action System (BAS), which has 3 subscales of its own: Reward Responsiveness (RR) 5 items about anticipation or occurrence of reward Drive (D) 4 items about pursuit of desired goals. Fun Seeking (FS) 4 items about desire for new rewards and impulsive approach to potential rewards.

  60 months

• Child's Mental Health Was Evaluated Using the Dominic Questionnaire.

  The Dominic questionnaire is a structured pictorial instrument assessing mental disorders in 6- to 11-year-old children. The Dominic assesses a child's perception of her/his own symptoms, which is critical to balance parents' and school professionals' perception. Ninety-nine drawings represent situations corresponding to DSM-III-R based. ADHD, Conduct Disorder, Oppositional Defiant Disorder, Major Depressive Disorder, Separation Anxiety Disorder, Generalized Anxiety Disorder and Specific Phobia.

  72 months

• The Child's Attributional Style Was Evaluated With the Child Attributional Style Interview.

  The Child Attributional Style Interview (CASI) is a measure of attributional style in children aged five years old and older. The interactive interview consists of sixteen events, which are presented to the child as illustrations, in a storybook format. The events are equally divided on two domains: valence (positive and negative theme), and interpersonal (parents and peers) and achievement. This creates the possibility of four sub-categories for analysis (i.e. positive-achievement, negative-interpersonal etc.). After the presentation of each event, the child is asked three questions for their level of internal, stable and global attributions for each event.

  72 months

• Changes in Child's Feeding Behaviour Was Measured With the Child Eating Behaviour Questionnaire.

  The Child Eating Behaviour Questionnaire (CEBQ) was designed to assess children's eating scale styles. It is a parent-report measure comprised of 35 items, each rated on a five-point likert scale that ranges from never to always. The instrument is ideal for use in research investigating the early precursors of eating disorders or obesity.

  48 and 72 months

• Child's Executive Functioning Measured With the Behavior Rating of Executive Function.

  The Behavior Rating Inventory of Executive Function (BRIEF) measures executive function behaviors for children and adolescents ages 5-18. Each form of the BRIEF parent- and teacher- rating form contains 86 items in eight non-overlapping clinical scales and two validity scales. These theoretically and statistically derived scales form two indexes: a) Behavioral Regulation (three scales) and b) Metacognition (five scales), as well as a Global Executive Composite score which takes into account all of the clinical scales and represents the child's overall executive function.

  72 months

• Sensitivity to Punishment & Sensitivity to Reward in Children Will be Evaluated Using the Child Version of the Sensitivity to Punishment & Sensitivity to Reward Questionnaire.

  The Sensitivity to Punishment \& Sensitivity to Reward questionnaire (SPSRQ-C) measures parent-rated sensitivity to punishment and reward and contains 33 items, divided in a Punishment Sensitivity scale, and three Reward Sensitivity scales: Reward Responsivity, Impulsivity/Fun-Seeking, and Drive. Each item is scored on a 5-point Likert scale.

  72 months

Secondary Outcomes (11)

• Changes in Mother's Depression Symptoms Measured With the Beck Depression Inventory.

  60 and 72 months

• Changes in Mother's Depression Symptoms Measured With the Center for Epidemiological Studies, Depression Scale.

  Prenatal, 6, 12, 24, 36, 48, 60, 72 months

• Changes in Mother's Depression Symptoms Were Measured With the Edinburgh Postnatal Depression Scale.

  6 months

• Changes in Mother's Anxiety Symptoms Were Measured Using the Speilberger State-Trait Anxiety Inventory.

  3, 24 and 60 months

• Mother's Retrospective Assessment of Parental Educational Style Using the Parental Bonding Inventory.

  6 months

Study Arms (1)

Prenatal and 3 to 72 months

Eligibility Criteria

• Age: 3 Months - 6 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Our community sample consisted of mothers recruited in Montréal (Québec) and Hamilton (Ontario), Canada, at 13 to 20 weeks' gestation. Participants were part of the Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN) study, which examines the development of individual differences in phenotypes associated with multiple forms of psychopathology. Mothers were first assessed during their pregnancy (∼26 weeks) and then followed at multiple time points that included home visits and laboratory sessions.

You may qualify if:

• Pregnant women recruited when they attending antenatal care clinics at the time of routine ultrasound or through advertisements at hospitals (usually at 13 to 20 weeks' gestation). Women were included in the study if they were 18 years of age or older, and fluent in either English or French. Only babies born at 37 weeks or later and above 2000 g were included in the MAVAN cohort.

Sponsors & Collaborators

• Douglas Mental Health University Institute: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• The JPB Foundation: collaborator
• Ludmer Family Foundation: collaborator
• Norlien Foundation: collaborator
• WOCO Foundation: collaborator
• Blema & Arnold Steinberg Family Foundation: collaborator
• McGill University: collaborator
• Jacobs Foundation: collaborator

Study Sites (1)

Douglas Mental Health University Institute

Verdun, Quebec, H4H 1R3, Canada

Location

Related Publications (43)

• O'Donnell KA, Gaudreau H, Colalillo S, Steiner M, Atkinson L, Moss E, Goldberg S, Karama S, Matthews SG, Lydon JE, Silveira PP, Wazana AD, Levitan RD, Sokolowski MB, Kennedy JL, Fleming A, Meaney MJ; MAVAN Research Team. The maternal adversity, vulnerability and neurodevelopment project: theory and methodology. Can J Psychiatry. 2014 Sep;59(9):497-508. doi: 10.1177/070674371405900906.

  PMID: 25565695 BACKGROUND

• Mileva-Seitz V, Kennedy J, Atkinson L, Steiner M, Levitan R, Matthews SG, Meaney MJ, Sokolowski MB, Fleming AS. Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants. Genes Brain Behav. 2011 Apr;10(3):325-33. doi: 10.1111/j.1601-183X.2010.00671.x. Epub 2011 Jan 13.

  PMID: 21232011 RESULT

• Silveira PP, Agranonik M, Faras H, Portella AK, Meaney MJ, Levitan RD; Maternal Adversity, Vulnerability and Neurodevelopment Study Team. Preliminary evidence for an impulsivity-based thrifty eating phenotype. Pediatr Res. 2012 Mar;71(3):293-8. doi: 10.1038/pr.2011.39. Epub 2012 Jan 25.

  PMID: 22278183 RESULT

• Mileva-Seitz V, Steiner M, Atkinson L, Meaney MJ, Levitan R, Kennedy JL, Sokolowski MB, Fleming AS. Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood. PLoS One. 2013 Apr 18;8(4):e61443. doi: 10.1371/journal.pone.0061443. Print 2013.

  PMID: 23637833 RESULT

• Jonas W, Mileva-Seitz V, Girard AW, Bisceglia R, Kennedy JL, Sokolowski M, Meaney MJ, Fleming AS, Steiner M; MAVAN Research Team. Genetic variation in oxytocin rs2740210 and early adversity associated with postpartum depression and breastfeeding duration. Genes Brain Behav. 2013 Oct;12(7):681-94. doi: 10.1111/gbb.12069. Epub 2013 Aug 31.

  PMID: 23941164 RESULT

• Adedinsewo DA, Fleming AS, Steiner M, Meaney MJ, Girard AW; MAVAN team. Maternal anxiety and breastfeeding: findings from the MAVAN (Maternal Adversity, Vulnerability and Neurodevelopment) Study. J Hum Lact. 2014 Feb;30(1):102-9. doi: 10.1177/0890334413504244. Epub 2013 Sep 24.

  PMID: 24065719 RESULT

• Silveira PP, Portella AK, Kennedy JL, Gaudreau H, Davis C, Steiner M, Soares CN, Matthews SG, Sokolowski MB, Dube L, Loucks EB, Hamilton J, Meaney MJ, Levitan RD; MAVAN Study Team. Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children. Appetite. 2014 Feb;73:15-22. doi: 10.1016/j.appet.2013.10.004. Epub 2013 Oct 20.

  PMID: 24153108 RESULT

• Neuwald MF, Agranonik M, Portella AK, Fleming A, Wazana A, Steiner M, Levitan RD, Meaney MJ, Silveira PP; MAVAN Study Team. Transgenerational effects of maternal care interact with fetal growth and influence attention skills at 18 months of age. Early Hum Dev. 2014 May;90(5):241-6. doi: 10.1016/j.earlhumdev.2014.01.015. Epub 2014 Mar 3.

  PMID: 24602473 RESULT

• Escobar RS, O'Donnell KA, Colalillo S, Pawlby S, Steiner M, Meaney MJ, Levitan RD, Silveira PP; MAVAN Study Team. Better quality of mother-child interaction at 4 years of age decreases emotional overeating in IUGR girls. Appetite. 2014 Oct;81:337-42. doi: 10.1016/j.appet.2014.06.107. Epub 2014 Jul 8.

  PMID: 25014742 RESULT

• Wendland BE, Atkinson L, Steiner M, Fleming AS, Pencharz P, Moss E, Gaudreau H, Silveira PP, Arenovich T, Matthews SG, Meaney MJ, Levitan RD; MAVAN Study Team. Low maternal sensitivity at 6 months of age predicts higher BMI in 48 month old girls but not boys. Appetite. 2014 Nov;82:97-102. doi: 10.1016/j.appet.2014.07.012. Epub 2014 Jul 15.

  PMID: 25049136 RESULT

• Pennestri MH, Moss E, O'Donnell K, Lecompte V, Bouvette-Turcot AA, Atkinson L, Minde K, Gruber R, Fleming AS, Meaney MJ, Gaudreau H; MAVAN Research Team. Establishment and consolidation of the sleep-wake cycle as a function of attachment pattern. Attach Hum Dev. 2015;17(1):23-42. doi: 10.1080/14616734.2014.953963. Epub 2014 Sep 18.

  PMID: 25231054 RESULT

• Levitan RD, Rivera J, Silveira PP, Steiner M, Gaudreau H, Hamilton J, Kennedy JL, Davis C, Dube L, Fellows L, Wazana A, Matthews S, Meaney MJ; MAVAN Study Team. Gender differences in the association between stop-signal reaction times, body mass indices and/or spontaneous food intake in pre-school children: an early model of compromised inhibitory control and obesity. Int J Obes (Lond). 2015 Apr;39(4):614-9. doi: 10.1038/ijo.2014.207. Epub 2014 Dec 16.

  PMID: 25512364 RESULT

• Bouvette-Turcot AA, Fleming AS, Wazana A, Sokolowski MB, Gaudreau H, Gonzalez A, Deslauriers J, Kennedy JL, Steiner M, Meaney MJ; MAVAN Research Team. Maternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype. Genes Brain Behav. 2015 Mar;14(3):229-37. doi: 10.1111/gbb.12205. Epub 2015 Mar 24.

  PMID: 25688466 RESULT

• Pennestri MH, Gaudreau H, Bouvette-Turcot AA, Moss E, Lecompte V, Atkinson L, Lydon J, Steiner M, Meaney MJ; Mavan Research Team. Attachment disorganization among children in Neonatal Intensive Care Unit: Preliminary results. Early Hum Dev. 2015 Oct;91(10):601-6. doi: 10.1016/j.earlhumdev.2015.07.005. Epub 2015 Aug 8.

  PMID: 26261864 RESULT

• Bouvette-Turcot AA, Pluess M, Bernier A, Pennestri MH, Levitan R, Sokolowski MB, Kennedy JL, Minde K, Steiner M, Pokhvisneva I, Meaney MJ, Gaudreau H; MAVAN research team. Effects of Genotype and Sleep on Temperament. Pediatrics. 2015 Oct;136(4):e914-21. doi: 10.1542/peds.2015-0080. Epub 2015 Sep 14.

  PMID: 26371199 RESULT

• Wazana A, Moss E, Jolicoeur-Martineau A, Graffi J, Tsabari G, Lecompte V, Pascuzzo K, Babineau V, Gordon-Green C, Mileva V, Atkinson L, Minde K, Bouvette-Turcot AA, Sassi R, St-Andre M, Carrey N, Matthews S, Sokolowski M, Lydon J, Gaudreau H, Steiner M, Kennedy JL, Fleming A, Levitan R, Meaney MJ. The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. Dev Psychopathol. 2015 Nov;27(4 Pt 1):1145-61. doi: 10.1017/S0954579415000735.

  PMID: 26439067 RESULT

• Reis RS, Bernardi JR, Steiner M, Meaney MJ, Levitan RD, Silveira PP; MAVAN Study Team. Poor infant inhibitory control predicts food fussiness in childhood - A possible protective role of n-3 PUFAs for vulnerable children. Prostaglandins Leukot Essent Fatty Acids. 2015 Jun;97:21-5. doi: 10.1016/j.plefa.2015.03.004. Epub 2015 Apr 3.

  PMID: 25892188 RESULT

• Babineau V, Green CG, Jolicoeur-Martineau A, Bouvette-Turcot AA, Minde K, Sassi R, St-Andre M, Carrey N, Atkinson L, Kennedy JL, Lydon J, Steiner M, Gaudreau H, Levitan R, Meaney M, Wazana A; MAVAN project. Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months--a differential susceptibility model. J Child Psychol Psychiatry. 2015 Jan;56(1):21-9. doi: 10.1111/jcpp.12246. Epub 2014 May 15.

  PMID: 24827922 RESULT

• Silveira PP, Gaudreau H, Atkinson L, Fleming AS, Sokolowski MB, Steiner M, Kennedy JL, Meaney MJ, Levitan RD, Dube L. Genetic Differential Susceptibility to Socioeconomic Status and Childhood Obesogenic Behavior: Why Targeted Prevention May Be the Best Societal Investment. JAMA Pediatr. 2016 Apr;170(4):359-64. doi: 10.1001/jamapediatrics.2015.4253.

  PMID: 26832777 RESULT

• Cost KT, Plamondon A, Unternaehrer E, Meaney M, Steiner M, Fleming AS; MAVAN team. The more things change, the more things stay the same: maternal attitudes 3 to 18 months postpartum. Acta Paediatr. 2016 Jul;105(7):e320-7. doi: 10.1111/apa.13409. Epub 2016 May 6.

  PMID: 26999290 RESULT

• Green CG, Babineau V, Jolicoeur-Martineau A, Bouvette-Turcot AA, Minde K, Sassi R, St-Andre M, Carrey N, Atkinson L, Kennedy JL, Steiner M, Lydon J, Gaudreau H, Burack JA, Levitan R, Meaney MJ, Wazana A; Maternal Adversity, Vulnerability, and Neurodevelopment Research Team. Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months. Dev Psychopathol. 2017 Aug;29(3):901-917. doi: 10.1017/S0954579416000560. Epub 2016 Jul 18.

  PMID: 27427178 RESULT

• Bouvette-Turcot AA, Unternaehrer E, Gaudreau H, Lydon JE, Steiner M, Meaney MJ; MAVAN Research Team. The joint contribution of maternal history of early adversity and adulthood depression to socioeconomic status and potential relevance for offspring development. J Affect Disord. 2017 Jan 1;207:26-31. doi: 10.1016/j.jad.2016.08.012. Epub 2016 Aug 16.

  PMID: 27685851 RESULT

• Tombeau Cost K, Unternaehrer E, Plamondon A, Steiner M, Meaney M, Atkinson L, Kennedy JL, Fleming AS; MAVAN Research Team. Thinking and doing: the effects of dopamine and oxytocin genes and executive function on mothering behaviours. Genes Brain Behav. 2017 Feb;16(2):285-295. doi: 10.1111/gbb.12337. Epub 2016 Oct 21.

  PMID: 27620964 RESULT

• Levitan RD, Jansen P, Wendland B, Tiemeier H, Jaddoe VW, Silveira PP, Kennedy JL, Atkinson L, Fleming A, Sokolowski M, Gaudreau H, Steiner M, Dube L, Hamilton J, Moss E, Wazana A, Meaney M. A DRD4 gene by maternal sensitivity interaction predicts risk for overweight or obesity in two independent cohorts of preschool children. J Child Psychol Psychiatry. 2017 Feb;58(2):180-188. doi: 10.1111/jcpp.12646. Epub 2016 Oct 11.

  PMID: 27726127 RESULT

• Maunder RG, Hunter JJ, Atkinson L, Steiner M, Wazana A, Fleming AS, Moss E, Gaudreau H, Meaney MJ, Levitan RD. An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults. Psychosom Med. 2017 Jun;79(5):506-513. doi: 10.1097/PSY.0000000000000437.

  PMID: 27941580 RESULT

• Pokhvisneva I, Leger E, Meaney MJ, Silveira PP. Systematic Overestimation of Reflection Impulsivity in the Information Sampling Task: Age Dependency in Children. Biol Psychiatry. 2018 Jan 15;83(2):e33-e34. doi: 10.1016/j.biopsych.2016.12.027. Epub 2017 Jan 5. No abstract available.

  PMID: 28189253 RESULT

• Bischoff AR, Pokhvisneva I, Leger E, Gaudreau H, Steiner M, Kennedy JL, O'Donnell KJ, Diorio J, Meaney MJ, Silveira PP; MAVAN research team. Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months. PLoS One. 2017 May 15;12(5):e0177344. doi: 10.1371/journal.pone.0177344. eCollection 2017.

  PMID: 28505190 RESULT

• Silveira PP, Pokhvisneva I, Gaudreau H, Atkinson L, Fleming AS, Sokolowski MB, Steiner M, Kennedy JL, Dube L, Levitan RD, Meaney MJ; MAVAN research team. Fetal growth interacts with multilocus genetic score reflecting dopamine signaling capacity to predict spontaneous sugar intake in children. Appetite. 2018 Jan 1;120:596-601. doi: 10.1016/j.appet.2017.10.021. Epub 2017 Oct 14.

  PMID: 29038017 RESULT

• Graffi J, Moss E, Jolicoeur-Martineau A, Moss G, Lecompte V, Pascuzzo K, Babineau V, Gordon-Green C, Mileva-Seitz VR, Minde K, Sassi R, Steiner M, Kennedy JL, Gaudreau H, Levitan R, Meaney MJ, Wazana A; MAVAN project. The dopamine D4 receptor gene, birth weight, maternal depression, maternal attention, and the prediction of disorganized attachment at 36 months of age: A prospective genexenvironment analysis. Infant Behav Dev. 2018 Feb;50:64-77. doi: 10.1016/j.infbeh.2017.11.004. Epub 2017 Nov 21.

  PMID: 29149620 RESULT

• Parent C, Pokhvisneva I, Gaudreau H, Diorio J, Meaney MJ, Silveira PP; MAVAN Research Team. Community study found that cutaneous allergies in childhood were associated with conduct problems in girls. Acta Paediatr. 2018 May;107(5):900-901. doi: 10.1111/apa.14235. Epub 2018 Feb 19. No abstract available.

  PMID: 29364555 RESULT

• Silveira PP, Pokhvisneva I, Gaudreau H, Rifkin-Graboi A, Broekman BFP, Steiner M, Levitan R, Parent C, Diorio J, Meaney MJ. Birth weight and catch up growth are associated with childhood impulsivity in two independent cohorts. Sci Rep. 2018 Sep 12;8(1):13705. doi: 10.1038/s41598-018-31816-5.

  PMID: 30209275 RESULT

• Jolicoeur-Martineau A, Wazana A, Szekely E, Steiner M, Fleming AS, Kennedy JL, Meaney MJ, Greenwood CMT. Alternating optimization for G x E modelling with weighted genetic and environmental scores: Examples from the MAVAN study. Psychol Methods. 2019 Apr;24(2):196-216. doi: 10.1037/met0000175. Epub 2018 Aug 13.

  PMID: 30102054 RESULT

• Belsky J, Pokhvisneva I, Rema ASS, Broekman BFP, Pluess M, O'Donnell KJ, Meaney MJ, Silveira PP. Polygenic differential susceptibility to prenatal adversity. Dev Psychopathol. 2019 May;31(2):439-441. doi: 10.1017/S0954579418000378. Epub 2018 Aug 7.

  PMID: 30081968 RESULT

• Laganiere C, Gaudreau H, Pokhvisneva I, Atkinson L, Meaney M, Pennestri MH. Maternal characteristics and behavioural/emotional problems in preschoolers: how they relate to sleep rhythmic movements at sleep onset. J Sleep Res. 2019 Jun;28(3):e12707. doi: 10.1111/jsr.12707. Epub 2018 Jun 5.

  PMID: 29873138 RESULT

• Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ; Mavan Study Team. The early care environment and DNA methylome variation in childhood. Dev Psychopathol. 2018 Aug;30(3):891-903. doi: 10.1017/S0954579418000627.

  PMID: 30068421 RESULT

• Jonas W, Bisceglia R, Meaney MJ, Dudin A, Fleming AS, Steiner M; MAVAN Research Team. The role of breastfeeding in the association between maternal and infant cortisol attunement in the first postpartum year. Acta Paediatr. 2018 Jul;107(7):1205-1217. doi: 10.1111/apa.14256. Epub 2018 Mar 24.

  PMID: 29405436 RESULT

• Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics. 2018;13(1):19-32. doi: 10.1080/15592294.2017.1411443. Epub 2018 Jan 30.

  PMID: 29381404 RESULT

• Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Dev Psychopathol. 2017 Dec;29(5):1601-1617. doi: 10.1017/S0954579417001262.

  PMID: 29162172 RESULT

• Agranonik M, Portella AK, Hamilton J, Fleming AS, Steiner M, Meaney MJ, Levitan RD, Silveira PP; MAVAN study team. Breastfeeding in the 21st century. Lancet. 2016 May 21;387(10033):2088-2089. doi: 10.1016/S0140-6736(16)30536-0. No abstract available.

  PMID: 27301818 RESULT

• Jonas W, Atkinson L, Steiner M, Meaney MJ, Wazana A, Fleming AS; MAVAN research team. Breastfeeding and maternal sensitivity predict early infant temperament. Acta Paediatr. 2015 Jul;104(7):678-86. doi: 10.1111/apa.12987. Epub 2015 Apr 22.

  PMID: 25727570 RESULT

• Graffi J, Moss E, Jolicoeur-Martineau A, Moss G, Lecompte V, Pascuzzo K, Babineau V, Gordon-Green C, Mileva-Seitz VR, Minde K, Sassi R, Carrey N, Kennedy JL, Gaudreau H, Levitan R, Meaney M, Wazana A. Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style. McGill Sci Undergrad Res J. 2015 Mar;10(1):31-36.

  PMID: 28574063 RESULT

• Agrati D, Browne D, Jonas W, Meaney M, Atkinson L, Steiner M, Fleming AS; MAVAN research team. Maternal anxiety from pregnancy to 2 years postpartum: transactional patterns of maternal early adversity and child temperament. Arch Womens Ment Health. 2015 Oct;18(5):693-705. doi: 10.1007/s00737-014-0491-y. Epub 2015 Jan 29.

  PMID: 25627018 RESULT

• Plamondon A, Akbari E, Atkinson L, Steiner M, Meaney MJ, Fleming AS; MAVAN research team. Spatial working memory and attention skills are predicted by maternal stress during pregnancy. Early Hum Dev. 2015 Jan;91(1):23-9. doi: 10.1016/j.earlhumdev.2014.11.004. Epub 2014 Nov 26.

  PMID: 25460253 RESULT

MeSH Terms

Conditions

Depression; Psychotic Disorders; Personality Disorders; Substance-Related Disorders; Infant Behavior; Fetal Growth Retardation

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Chemically-Induced Disorders; Child Behavior; Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr Patricia Pelufo Silveira
• Organization: Douglas Mental Health University Institute

patricia.silveira@mcgill.ca

1514-761-6131

Study Officials

• Michael J Meaney, PhD

  James McGill Professor

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: James McGill professor

Study Record Dates

• First Submitted: January 30, 2018
• First Posted: February 15, 2018
• Study Start: October 1, 2003
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: May 27, 2020
• Results First Posted: May 27, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)