Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies
1 other identifier
observational
40,641
1 country
1
Brief Summary
Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 20, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 28, 2017
CompletedFirst Submitted
Initial submission to the registry
February 7, 2018
CompletedFirst Posted
Study publicly available on registry
February 14, 2018
CompletedFebruary 22, 2018
February 1, 2018
19 days
February 7, 2018
February 15, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Gastrointestinal Tract Cancer Incident Measure
The gastrointestinal tract cancer incident would be recorded during the follow-up years.
Through study completion, an average of 5 years.
Study Arms (10)
Jing Huang et. al, 2017
Max Leenders et. al,2014
Yusuke Okuyama et. al,2014
GC Kabat et. al,2012
Christina Persson et. al,2008
M Jenab et. al,2006
Kenji Wakai et. al,2005
Christian C. Abnet et. al,2003
N Malila et. al,2002
G Pappalardo et. al,1997
Interventions
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Eligibility Criteria
The study population include people from primary care clinic or community sample.
You may qualify if:
- The study had both case and control groups
- Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported
- Patients in case group were diagnosed with GIT cancer
You may not qualify if:
- ·Animal studies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
Related Publications (1)
Huang J, Lu MS, Fang YJ, Xu M, Huang WQ, Pan ZZ, Chen YM, Zhang CX. Serum carotenoids and colorectal cancer risk: A case-control study in Guangdong, China. Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700267. Epub 2017 Jul 31.
PMID: 28605127RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- West China Hospital
Study Record Dates
First Submitted
February 7, 2018
First Posted
February 14, 2018
Study Start
November 1, 2017
Primary Completion
November 20, 2017
Study Completion
December 28, 2017
Last Updated
February 22, 2018
Record last verified: 2018-02
Data Sharing
- IPD Sharing
- Will not share