Acromegaly - Before and After Treatment
Sleep Apnea, Circulation and Metabolism in Acromegaly - Before and After Treatment
1 other identifier
observational
20
1 country
1
Brief Summary
The aim of the study is to investigate sleep apnea, circulation and metabolism in acromegaly before and after surgery and/or medical treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2017
CompletedFirst Submitted
Initial submission to the registry
December 22, 2017
CompletedFirst Posted
Study publicly available on registry
February 13, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedDecember 7, 2020
December 1, 2020
5.2 years
December 22, 2017
December 4, 2020
Conditions
Outcome Measures
Primary Outcomes (3)
Sleep apnea
ApneaLinkAir: respiratory effort, puls, oxygen saturation, nasal flow and snoring
At baseline (time of diagnosis) and at an average of 1 years treatment
Circulation
Sphygmocor: central arterial pressure and pulse wave velocity
At baseline (time of diagnosis) and at an average of 1 years treatment
Bone metabolism
HRpQCT scan
At baseline (time of diagnosis) and at an average of 1 years treatment
Secondary Outcomes (6)
Heartfunction
At baseline (time of diagnosis) and at an average of 1 years treatment
Substrate metabolism; signaling proteins
At baseline (time of diagnosis) and at an average of 1 years treatment
Substrate metabolism; gene targets
At baseline (time of diagnosis) and at an average of 1 years treatment
Energy expenditure
At baseline (time of diagnosis) and at an average of 1 years treatment
Body composition
At baseline (time of diagnosis) and at an average of 1 years treatment
- +1 more secondary outcomes
Eligibility Criteria
Newly diagnosed acromegalic patients
You may qualify if:
- Recently diagnosed with acromegaly
- Age above 18
- Written consent
You may not qualify if:
- \- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Aarhus University Hospital, Department of internal medicine and endocrinologi
Aarhus, 8000, Denmark
Biospecimen
Blood samples and tissue will be kept in a locked freezer thorughout the study period
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jens Otto L Jørgensen, Porfessor
Aarhus University Hospital, Department of internal medicine and endocrinology
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 22, 2017
First Posted
February 13, 2018
Study Start
October 1, 2017
Primary Completion
December 1, 2022
Study Completion
December 1, 2022
Last Updated
December 7, 2020
Record last verified: 2020-12
Data Sharing
- IPD Sharing
- Will not share