Sweden Cancerome Analysis Network - Breast (SCAN-B) Coupled to Psychological Resilience

NCT03430492 | Active Not Recruiting

• 1 other identifier: SCAN-B Resilience
• Study Type: observational
• Target: 985
• Locations: 1 country
• Sites: 4

Brief Summary

This study aims to define the association between psychological resilience and biomolecular signatures in cancer patients and to relate psychological resilience to prognosis, as this could potentially open up a novel avenue of therapeutic interventions, medical as well as psychosocial.

Conditions

Breast Cancer

Keywords

Psychological Resilience; Biomarkers; Molecular Fingerprint; Quality of Life (QoL); Body and Mind; CD-RISC; SF-36

Outcome Measures

Primary Outcomes (1)

• The association between psychological resilience and biomolecular signatures in breast cancer patients

  Measured by CD-RISC and bimolecular techniques.

  All patients enrolled 2019-12-31. Analysis 2020-2022

Secondary Outcomes (6)

• The association between psychological resilience and quality of life at baseline in breast cancer patients

  All patients enrolled 2019-12-31. Analysis 2020-2022

• The association between psychological resilience and quality of life one year after diagnosis in breast cancer patients

  Patients followed up one year from diagnosis. All patients enrolled 2019-12-31. Analysis 2020-2022

• The association between psychological resilience and recovery/rehabilitation five years after

  Patients followed up five years from diagnosis. All patients enrolled 2019-12-31. Analysis 2020-2024

• The association between psychological resilience and prognosis in breast cancer patients

  Patients followed up one year from diagnosis. All patients enrolled 2019-12-31. Analysis 2020-2024

• The association between psychological resilience and clinicopathological characteristics

  All patients enrolled 2019-12-31. Analysis 2020-2024

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: The study includes only women with newly diagnosed breast cancer
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

SCAN-B Resilience is, as a part of the SCAN-B program, a prospective breast cancer study with established infrastructure for enrollment and follow-ups for patient. The study population is newly diagnosed breast cancer patients enrolled in SCAN-B at the hospitals in Karlskrona, Helsingborg, Växjö and Halmstad. The INCA register (a information network for cancer care) includes almost 100% of all women diagnosed with breast cancer. Based on comparison with cancer registrations in INCA for 2011-2012, 85 % of all new breast cancer diagnosed women are included in SCAN-B. In April 2017 83% of patients included in SCAN-B were also enrolled in SCAN-B Resilience why a majority (70%) of women diagnosed with breast cancer are enrolled in this study

You may qualify if:

• Newly diagnosed patients with primary breast cancer
• Patients consented to be included in the SCAN-B study at (Blekinge County Hospital, Central Hospital Växjö and Hallands Hospital Halmstad HBG??
• Oral and written consent for the SCAN-B Resilience study
• Age ≥ 18 years
• Patients that do understand the Swedish language (written and spoken)

You may not qualify if:

• No diagnosis of breast cancer
• Not consented to be included in the SCAN-B study
• Do not understand the Swedish language

Sponsors & Collaborators

• Lund University: lead
• Vinnova: collaborator
• Mats Paulssons stiftelse, org. nr 802423-3150: collaborator
• Gunnar Nilsson's Cancer Foundation: collaborator
• CREATE Health Cancer Centre: collaborator

Study Sites (4)

Blekinge County Hospital

Karlskrona, Blekinge County, 37480, Sweden

Location

Hallands Hospital Halmstad

Halmstad, Halland County, 30185, Sweden

Location

Helsingborgs hospital

Helsingborg, Skåne County, 25187, Sweden

Location

Central Hospital Växjö

Vaxjo, Småland, 35185, Sweden

Location

Related Publications (5)

• Saal LH, Vallon-Christersson J, Hakkinen J, Hegardt C, Grabau D, Winter C, Brueffer C, Tang MH, Reutersward C, Schulz R, Karlsson A, Ehinger A, Malina J, Manjer J, Malmberg M, Larsson C, Ryden L, Loman N, Borg A. The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine. Genome Med. 2015 Feb 2;7(1):20. doi: 10.1186/s13073-015-0131-9. eCollection 2015.

  PMID: 25722745 BACKGROUND

• Axelsson U, Ryden L, Johnsson P, Eden P, Mansson J, Hallberg IR, Borrebaeck CAK. A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study. BMC Cancer. 2018 Aug 6;18(1):789. doi: 10.1186/s12885-018-4669-y.

  PMID: 30081937 BACKGROUND

• Mohlin A, Bendahl PO, Hegardt C, Richter C, Hallberg IR, Ryden L. Psychological Resilience and Health-Related Quality of Life in 418 Swedish Women with Primary Breast Cancer: Results from a Prospective Longitudinal Study. Cancers (Basel). 2021 May 6;13(9):2233. doi: 10.3390/cancers13092233.

  PMID: 34066499 RESULT

• Mohlin A, Axelsson U, Bendahl PO, Borrebaeck C, Hegardt C, Johnsson P, Rahm Hallberg I, Ryden L. Psychological Resilience and Health-Related Quality of Life in Swedish Women with Newly Diagnosed Breast Cancer. Cancer Manag Res. 2020 Nov 24;12:12041-12051. doi: 10.2147/CMAR.S268774. eCollection 2020.

  PMID: 33269004 RESULT

• Velickovic K, Borrebaeck CAK, Bendahl PO, Hegardt C, Johnsson P, Richter C, Ryden L, Hallberg IR. One-year recovery from breast cancer: Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life. Front Oncol. 2022 Aug 16;12:891850. doi: 10.3389/fonc.2022.891850. eCollection 2022.

  PMID: 36052232 RESULT

Related Links

• SCAN-B homepage

Biospecimen

Retention: SAMPLES WITH DNA

Whole Blood

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Carl AK Borrebaeck, Professor

  Lund University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2018
• First Posted: February 13, 2018
• Study Start: February 15, 2016
• Primary Completion: February 28, 2025
• Study Completion: December 31, 2025
• Last Updated: March 19, 2025

Record last verified: 2025-03

Locations

SE (4)