NCT03427931

Brief Summary

A study assessing glucose variability in subjects with Type 1 Diabetes who have had islet transplant.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
7

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 29, 2017

Completed
1 month until next milestone

Study Start

First participant enrolled

February 1, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 9, 2018

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 11, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 11, 2019

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

August 7, 2020

Completed
Last Updated

August 7, 2020

Status Verified

July 1, 2020

Enrollment Period

1.4 years

First QC Date

December 29, 2017

Results QC Date

July 11, 2020

Last Update Submit

July 23, 2020

Conditions

Keywords

Type 1 Diabetes MellitusIslet TransplantationContinuous Glucose Monitor (CGM)

Outcome Measures

Primary Outcomes (1)

  • Percentage Time in Range 70-180 mg/dL by CGM

    Descriptive analysis for CGM use measuring percentage time in range of glucose between 70-180 mg/dL

    28-90 days

Secondary Outcomes (1)

  • Percentage Time in Range <70 mg/dL by CGM

    28-90 days

Study Arms (1)

Continuous Glucose Monitor (CGM)

EXPERIMENTAL

Study subjects will collect Continuous Glucose Monitor data by wearing the device at home a minimum of 28 days but may continue for up to 3 months.

Other: Continuous Glucose Monitor (CGM)

Interventions

Study subjects will collect Continuous Glucose Monitor data for a minimum of 28 days but may continue for up to 3 months.

Continuous Glucose Monitor (CGM)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Type 1 Diabetes Mellitus
  • Recipient of Islet Transplantation
  • Age 18 or older
  • Females, not currently know to be pregnant
  • Demonstration of proper mental status and cognition for the study
  • Understanding and willingness to follow the protocol and informed consent form
  • Access to the internet and willingness to upload data during the study, including use of personal laptop

You may not qualify if:

  • Pregnancy and intent to become pregnant during trial
  • Use of acetaminophen (such as Tylenol)
  • Current enrollment in another intervention clinical trial that affects glucose variability

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Virginia Center for Diabetes Technology

Charlottesville, Virginia, 22903, United States

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Sue Brown, MD
Organization
University of Virginia

Study Officials

  • Sue A Brown, MD

    University of Virginia

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 29, 2017

First Posted

February 9, 2018

Study Start

February 1, 2018

Primary Completion

July 11, 2019

Study Completion

July 11, 2019

Last Updated

August 7, 2020

Results First Posted

August 7, 2020

Record last verified: 2020-07

Locations