NCT03422718

Brief Summary

This study evaluates a health theory based mobile health behavioral intervention to reduce blood pressure (BP) among hypertensive patients evaluated in a community Emergency Department (ED) setting.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
488

participants targeted

Target at P75+ for not_applicable hypertension

Timeline
Completed

Started Mar 2019

Typical duration for not_applicable hypertension

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 30, 2018

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 6, 2018

Completed
1.1 years until next milestone

Study Start

First participant enrolled

March 25, 2019

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 8, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 8, 2021

Completed
3.2 years until next milestone

Results Posted

Study results publicly available

June 20, 2024

Completed
Last Updated

June 20, 2024

Status Verified

May 1, 2024

Enrollment Period

2 years

First QC Date

January 30, 2018

Results QC Date

November 15, 2023

Last Update Submit

May 23, 2024

Conditions

Keywords

strokehypertension

Outcome Measures

Primary Outcomes (1)

  • Change in Mean Systolic Blood Pressure

    Change in 12-month Systolic Blood Pressure (SBP)

    12 months

Secondary Outcomes (2)

  • Hazard Ratio Analysis of Participant Time From Enrollment Emergency Department Visit to the First PCP Visit

    Baseline ED visit (in days)

  • Odds Ratio Analysis of Participants Completing 2 or More Primary Care Visits

    12 months

Study Arms (8)

Arm 1

EXPERIMENTAL

No healthy behavior texts BP Monitoring Weekly Via Text Messaging No physician appointment and transportation scheduling

Behavioral: No healthy behavior textsBehavioral: BP Monitoring Weekly Via Text MessagingBehavioral: No physician appointment and transportation scheduling

Arm 2

EXPERIMENTAL

Healthy Behavior Texts BP Monitoring Weekly Via Text Messaging No physician appointment and transportation scheduling

Behavioral: Healthy Behavior TextsBehavioral: BP Monitoring Weekly Via Text MessagingBehavioral: No physician appointment and transportation scheduling

Arm 3

EXPERIMENTAL

No healthy behavior texts BP Monitoring Daily Via Text Messaging No physician appointment and transportation scheduling

Behavioral: No healthy behavior textsBehavioral: BP Monitoring Daily Via Text MessagingBehavioral: No physician appointment and transportation scheduling

Arm 4

EXPERIMENTAL

Healthy Behavior Texts BP Monitoring Daily Via Text Messaging No physician appointment and transportation scheduling

Behavioral: Healthy Behavior TextsBehavioral: BP Monitoring Daily Via Text MessagingBehavioral: No physician appointment and transportation scheduling

Arm 5

EXPERIMENTAL

No healthy behavior texts BP Monitoring Weekly Via Text Messaging Physician appointment and transportation scheduling

Behavioral: No healthy behavior textsBehavioral: BP Monitoring Weekly Via Text MessagingBehavioral: Physician appointment and transportation scheduling

Arm 6

EXPERIMENTAL

Healthy Behavior Texts BP Monitoring Weekly Via Text Messaging Physician appointment and transportation scheduling

Behavioral: Healthy Behavior TextsBehavioral: BP Monitoring Weekly Via Text MessagingBehavioral: Physician appointment and transportation scheduling

Arm 7

EXPERIMENTAL

No healthy behavior texts BP Monitoring Daily Via Text Messaging Physician appointment and transportation scheduling

Behavioral: No healthy behavior textsBehavioral: BP Monitoring Daily Via Text MessagingBehavioral: Physician appointment and transportation scheduling

Arm 8

EXPERIMENTAL

Healthy Behavior Texts BP Monitoring Daily Via Text Messaging Physician appointment and transportation scheduling

Behavioral: Healthy Behavior TextsBehavioral: BP Monitoring Daily Via Text MessagingBehavioral: Physician appointment and transportation scheduling

Interventions

Participants receive motivational health behavior texts

Arm 2Arm 4Arm 6Arm 8

Participants do not receive healthy behavior texts

Arm 1Arm 3Arm 5Arm 7

Daily text messages will prompt participants for BP by home cuff

Arm 3Arm 4Arm 7Arm 8

Weekly text messages will prompt participants for BP by home cuff

Arm 1Arm 2Arm 5Arm 6

Participants receive assistance scheduling physician appointment and transportation to those appointments

Arm 5Arm 6Arm 7Arm 8

Participants do not receive assistance scheduling physician appointment or transportation

Arm 1Arm 2Arm 3Arm 4

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age of 18 or greater
  • At least one BP with Systolic Blood Pressure (SBP) ≥ 160 or a Diastolic Blood Pressure (DBP) ≥ 100 (criteria 1)
  • If the patient has repeated measurements after achieving Criteria 1, at least one of the repeat BP remains SBP ≥ 140 or a DBP ≥ 90
  • Must have cell phones with text-messaging capability and willingness to receive texts
  • Likely to be discharged from the ED

You may not qualify if:

  • Unable to read English (\<1% at study site)
  • Prisoners
  • Pregnant
  • Pre-existing condition making one year follow-up unlikely
  • Terminal illness with death expected within 90 days
  • Current use of 3 or more antihypertensive agents
  • Patients with other serious medical conditions that prevent self-monitoring of BP
  • Critical illness with placement in resuscitation bay
  • Dementia/cognitive impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hurley Medical Center

Flint, Michigan, 48503, United States

Location

Related Publications (4)

  • Dinh M, Lin CC, Whitfield C, Farhan Z, Meurer WJ, Bailey S, Skolarus LE. Exploring the Acceptability and Feasibility of Remote Blood Pressure Measurements and Cognition Assessments Among Participants Recruited From a Safety-Net Emergency Department (Reach Out Cognition): Nonrandomized Mobile Health Trial. JMIR Form Res. 2024 May 28;8:e54010. doi: 10.2196/54010.

  • Skolarus LE, Dinh M, Kidwell KM, Lin CC, Buis LR, Brown DL, Oteng R, Giacalone M, Warden K, Trimble DE, Whitfield C, Farhan Z, Flood A, Borgialli D, Montas S, Jaggi M, Meurer WJ. Reach Out Emergency Department: A Randomized Factorial Trial to Determine the Optimal Mobile Health Components to Reduce Blood Pressure. Circ Cardiovasc Qual Outcomes. 2023 May;16(5):e009606. doi: 10.1161/CIRCOUTCOMES.122.009606. Epub 2023 May 16.

  • Skolarus LE, Dinh M, Kidwell KM, Farhan Z, Whitfield C, Levine DA, Meurer WJ. Supplement study update for Reach Out: a multi-arm randomized trial of behavioral interventions for hypertension initiated in the emergency department: Reach Out Cognition. Trials. 2021 Nov 24;22(1):836. doi: 10.1186/s13063-021-05806-4.

  • Meurer WJ, Dinh M, Kidwell KM, Flood A, Champoux E, Whitfield C, Trimble D, Cowdery J, Borgialli D, Montas S, Cunningham R, Buis LR, Brown D, Skolarus L. Reach out behavioral intervention for hypertension initiated in the emergency department connecting multiple health systems: study protocol for a randomized control trial. Trials. 2020 Jun 3;21(1):456. doi: 10.1186/s13063-020-04340-z.

MeSH Terms

Conditions

HypertensionStroke

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Results Point of Contact

Title
Principal Investigator
Organization
University of Michigan

Study Officials

  • William Meurer, MD

    University of Michigan

    PRINCIPAL INVESTIGATOR
  • Lesli Skolarus, MD

    University of Michigan

    PRINCIPAL INVESTIGATOR
  • Mackenzie Dinh, MS

    University of Michigan

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Emergency Medicine

Study Record Dates

First Submitted

January 30, 2018

First Posted

February 6, 2018

Study Start

March 25, 2019

Primary Completion

April 8, 2021

Study Completion

April 8, 2021

Last Updated

June 20, 2024

Results First Posted

June 20, 2024

Record last verified: 2024-05

Locations