PBMT on Muscular Performance and Recovery in Different Time-points

NCT03420391 | Completed DMC

• 1 other identifier: 113553
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

Conditions

Phototherapy

Keywords

phototherapy; performance; muscular recovery; photobiomodulation therapy; time-window

Outcome Measures

Primary Outcomes (1)

• Torque peak / maximum voluntary contraction - MVC

  Assessment was performed in the isokinetic dynamometer (System 4, Biodex®, USA)

  1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Secondary Outcomes (2)

• Delayed onset muscle soreness (DOMS)

  1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

• Biochemical marker of muscle damage

  1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Study Arms (6)

Placebo PBMT

PLACEBO COMPARATOR

Participants will be treated with placebo PBMT in different time-points before the eccentric exercise protocol (5 minutes, 3 hours, 6 hours or 24 hours). Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Device: Photobiomodulation Therapy (PBMT)

5 Minutes

ACTIVE COMPARATOR

Participants will be performed the eccentric exercise protocol 5 minutes after PBMT. Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Device: Photobiomodulation Therapy (PBMT)

3 Hours

ACTIVE COMPARATOR

3 hours: Participants will be performed the eccentric exercise protocol 3 hours after PBMT. Assessments will be performed before at baseline, 1 minute, 1 hour and 24, 48 hours after the end of exercise protocol.

Device: Photobiomodulation Therapy (PBMT)

6 Hours

ACTIVE COMPARATOR

6 hours: Participants will be performed the eccentric exercise protocol 6 hours after PBMT. Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Device: Photobiomodulation Therapy (PBMT)

24 hours

ACTIVE COMPARATOR

24 hours: Participants will be performed the eccentric exercise protocol 24 hours after PBMT. Assessments will be performed before at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Device: Photobiomodulation Therapy (PBMT)

Control

NO INTERVENTION

Participants will not receive intervention. Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Interventions

Photobiomodulation Therapy (PBMT) DEVICE

Phototherapy device - Multi Radiance Medical® (Solon, OH, EUA)

24 hours; 3 Hours; 5 Minutes; 6 Hours; Placebo PBMT

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• not athletes or who engage in physical activity at most once a week
• Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies
• they should not be using pharmacological agents and / or nutritional supplements
• They must attend 100% of the data collections.

You may not qualify if:

• Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Sponsors & Collaborators

• University of Nove de Julho: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator
• University of Bergen: collaborator

Study Sites (1)

Universidade Nove de Julho

São Paulo, 01504-001, Brazil

Location

Related Publications (1)

• Leal-Junior ECP, de Oliveira MFD, Joensen J, Stausholm MB, Bjordal JM, Tomazoni SS. What is the optimal time-response window for the use of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) for the improvement of exercise performance and recovery, and for how long the effects last? A randomized, triple-blinded, placebo-controlled trial. BMC Sports Sci Med Rehabil. 2020 Oct 19;12:64. doi: 10.1186/s13102-020-00214-8. eCollection 2020.

  PMID: 33088573 DERIVED

MeSH Terms

Interventions

Low-Level Light Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Full professor

Model Details: Sixty participants will be enrolled in the study. Participants will be randomized in six groups: Control: Participants will receive no intervention; Placebo: Participants will receive placebo PBMT; 5 minutes: Participants will perform the eccentric exercise protocol 5 minutes after PBMT. 3 hours: Participants will perform the eccentric exercise protocol 3 hours after PBMT. 6 hours: Participants will perform the eccentric exercise protocol 6 hours after PBMT. 24 hours: Participants will perform the eccentric exercise protocol 24 hours after PBMT. Assessments will be performed at baseline, after 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Study Record Dates

• First Submitted: January 20, 2018
• First Posted: February 5, 2018
• Study Start: May 20, 2019
• Primary Completion: July 19, 2019
• Study Completion: July 19, 2019
• Last Updated: April 28, 2020

Record last verified: 2020-04

Locations

BR (1)