Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

NCT03419273 | Completed

• 1 other identifier: Bariatric surgery
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Conditions

Obesity, Morbid; Bariatric Surgery Candidate

Outcome Measures

Primary Outcomes (3)

• TNFa

  TNFa

  measured in the one sample collected at surgery

• Il-6

  Il-6

  measured in the one sample collected at surgery

• macrophage

  macrophage

  measured in the one sample collected at surgery

Interventions

bariatric surgery PROCEDURE

We are recruiting only those going through bariatric surgery

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

You may qualify if:

• Women who are premenopausal or who are postmenopausal and have been for at least one year.
• Males will be recruited to age match female subjects. All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

You may not qualify if:

• Women who are perimenopausal. Women who are on Hormone Replacement Therapy.

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

Related Publications (1)

• Porter JW, Barnas JL, Welly R, Spencer N, Pitt J, Vieira-Potter VJ, Kanaley JA. Age, Sex, and Depot-Specific Differences in Adipose-Tissue Estrogen Receptors in Individuals with Obesity. Obesity (Silver Spring). 2020 Sep;28(9):1698-1707. doi: 10.1002/oby.22888. Epub 2020 Jul 31.

  PMID: 32734695 DERIVED

MeSH Terms

Conditions

Obesity, Morbid

Interventions

Bariatric Surgery

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Bariatrics; Obesity Management; Therapeutics; Surgical Procedures, Operative

Study Officials

• Jill Kanaley, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 20, 2018
• First Posted: February 1, 2018
• Study Start: July 1, 2017
• Primary Completion: March 31, 2019
• Study Completion: July 1, 2019
• Last Updated: October 3, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)