Vitamin D as a Factor Modifying Adaptation to Exercise

NCT03417700 | Completed

• 1 other identifier: 2014/15/B/NZ7/00976
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

Physical activity is a recommended, indispensable element of a healthy lifestyle as well as a countermeasure against many diseases often accompanied by the acute or chronic low grade inflammation. Papers published in recent years have demonstrated the anti-inflammatory effect of exercise. Based on current knowledge of the topic, own experience and preliminary work, it is expected the proposed research to provide information on the mechanism either determining or limiting pro-healthy effects of exercise in different age groups of people. Three different training programmes will be investigated. Specific goals of the project include the following:

1. 1.Establish, whether regular Nordic Walking training and HIIT can reduce the low-grade systemic inflammation and which type of training is the most effective at doing so.
2. 2.Establish, whether regular training can prevent muscle sarcopenia and assess if those changes are related to the concentration of the autophagy-inducing stress protein, HMGB1.
3. 3.Establish, whether regular Nordic Walking training alters iron metabolism and evaluate its correlation with the inflammatory markers and bone-morphogenesis.
4. 4.Establish, whether muscle-released irisin signals growth in the BDNF concentration in response to exercise and if these changes improve cognitive function.
5. 5.Establish, whether Nordic Walking or HIIT training effectively improve the blood lipid profile and aerobic capacity, and if these effects correlate with the blood 25-OHD concentration.
6. 6.Establish, whether concentration of vitamin D alters adaptation to training and modifies immunological response to regular training process.

Conditions

Vitamin D3 Deficiency

Keywords

vitamin D; exercise; training; aging

Outcome Measures

Primary Outcomes (1)

• The influence of vitamin D on physical performance in aging people

  To verify if training supported by vitamin D supplementation will bring better effects

  Values at baseline will be compared to values recorded 12 weeks and 3 months after the training programme.

Study Arms (3)

Training NW

EXPERIMENTAL

exercise and supplementation

Dietary Supplement: NW training; Dietary Supplement: Placebo

Training HICT and vitamin D

EXPERIMENTAL

Training HICT plus vitamin D

Dietary Supplement: NW training; Dietary Supplement: Placebo; Dietary Supplement: HICT

Placebo

EXPERIMENTAL

placebo Vitamin D

Dietary Supplement: NW training

Interventions

NW training DIETARY_SUPPLEMENT

NW training

Also known as: Training, vitamin D

Placebo; Training HICT and vitamin D; Training NW

Placebo DIETARY_SUPPLEMENT

training with placebo

Also known as: Control group

Training HICT and vitamin D; Training NW

HICT DIETARY_SUPPLEMENT

Training and vitamin D

Also known as: resistance training

Training HICT and vitamin D

Eligibility Criteria

• Age: 15 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• no illness medical check

You may not qualify if:

• uncontrolled hypertension (diastolic blood pressure over 100 mmHg), a history of cardiac arrhythmia, cardio-respiratory disorders, advanced osteoporosis, clinical diagnosis of Alzheimer's Disease

Sponsors & Collaborators

• Gdansk University of Physical Education and Sport: lead

Study Sites (2)

University of Physical Education and Sport

Gdansk, Pomeranian Voivodeship, 80-336, Poland

Location

Ziemann Ewa

Sopot, Pomeranian Voivodeship, 81-735, Poland

Location

Related Publications (6)

• Gmiat A, Mieszkowski J, Prusik K, Prusik K, Kortas J, Kochanowicz A, Radulska A, Lipinski M, Tomczyk M, Jaworska J, Antosiewicz J, Ziemann E. Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. Biogerontology. 2017 Aug;18(4):535-548. doi: 10.1007/s10522-017-9694-8. Epub 2017 Mar 18.

  PMID: 28316011 RESULT

• Prusik K, Kortas J, Prusik K, Mieszkowski J, Jaworska J, Skrobot W, Lipinski M, Ziemann E, Antosiewicz J. Nordic Walking Training Causes a Decrease in Blood Cholesterol in Elderly Women Supplemented with Vitamin D. Front Endocrinol (Lausanne). 2018 Feb 20;9:42. doi: 10.3389/fendo.2018.00042. eCollection 2018.

  PMID: 29515518 RESULT

• Walentukiewicz A, Lysak-Radomska A, Jaworska J, Prusik K, Prusik K, Kortas JA, Lipinski M, Babinska A, Antosiewicz J, Ziemann E. Vitamin D Supplementation and Nordic Walking Training Decreases Serum Homocysteine and Ferritin in Elderly Women. Int J Environ Res Public Health. 2018 Sep 20;15(10):2064. doi: 10.3390/ijerph15102064.

  PMID: 30241318 RESULT

• Mieszkowski J, Niespodzinski B, Kochanowicz A, Gmiat A, Prusik K, Prusik K, Kortas J, Ziemann E, Antosiewicz J. The Effect of Nordic Walking Training Combined with Vitamin D Supplementation on Postural Control and Muscle Strength in Elderly People-A Randomized Controlled Trial. Int J Environ Res Public Health. 2018 Sep 7;15(9):1951. doi: 10.3390/ijerph15091951.

  PMID: 30205445 RESULT

• Gmiat A, Jaworska J, Micielska K, Kortas J, Prusik K, Prusik K, Lipowski M, Radulska A, Szupryczynska N, Antosiewicz J, Ziemann E. Improvement of cognitive functions in response to a regular Nordic walking training in elderly women - A change dependent on the training experience. Exp Gerontol. 2018 Apr;104:105-112. doi: 10.1016/j.exger.2018.02.006. Epub 2018 Feb 9.

  PMID: 29432893 RESULT

• Kortas J, Kuchta A, Prusik K, Prusik K, Ziemann E, Labudda S, Cwiklinska A, Wieczorek E, Jankowski M, Antosiewicz J. Nordic walking training attenuation of oxidative stress in association with a drop in body iron stores in elderly women. Biogerontology. 2017 Aug;18(4):517-524. doi: 10.1007/s10522-017-9681-0. Epub 2017 Feb 22.

  PMID: 28229255 RESULT

MeSH Terms

Conditions

Motor Activity

Interventions

Vitamin D; Control Groups; Resistance Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Secosteroids; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ewa Ziemann

  Gdansk University of Physical Education and Sport, Poland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Participants will receive vitamin D supplementation, but the dose will be known only to one investigator, who will be not be participating in any other assessment.
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Model I Women and men over 65 years old will participate in the training programme. All subjects will undergo a medical check-up before being subject to exercise. All procedures will be performed with the approval from the Bioethical Committee of the Regional Medical Society in Gdansk. One week prior to the beginning of the experiment, a battery of physiological and psychological tests will be performed. The same procedure will be repeated after the training period. In addtition to training, supplementation of vitamin D (800IU and 4000IU) will be administered. Model II Young women will participate in the training programme. They will perform a high-intensity circuit training according to the ACSM. They will perform a single session of HICT and 12 units of HICT regularly. One week prior to the beginning of the experiment, a battery of physiological and psychological test will be performed. The same procedure will be repeated after the training period.

Study Record Dates

• First Submitted: November 30, 2017
• First Posted: January 31, 2018
• Study Start: January 5, 2018
• Primary Completion: January 1, 2020
• Study Completion: January 10, 2020
• Last Updated: May 11, 2021

Record last verified: 2021-05

Data Sharing

• IPD Sharing: Will not share

Locations

PL (2)