Frailty in Older HIV-infected Individuals
1 other identifier
observational
100
1 country
1
Brief Summary
Frailty has been proposed as a measure of biological (as opposed to chronological) aging. In this study the investigators plan to: (1) measure frailty in a cohort of older HIV-infected individuals in Hong Kong, and its association with mortality and quality of life; (2) identify risk factors predictive of development of frailty in HIV-infected individuals in Hong Kong; and (3) determine the outcomes of HIV-infected individuals in Hong Kong with and without frailty. The following assessment will be done:
- 1.Physical examination including measuring height, weight, hip and waist circumference.
- 2.Grip strength, chair stand test, gait speed test, balance tests, and neurocognitive tests
- 3.Geriatric syndromes, screening for depression, disability and quality of life.
- 4.Blood tests during fasting state to measure metabolic parameters.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 23, 2018
CompletedFirst Posted
Study publicly available on registry
January 29, 2018
CompletedStudy Start
First participant enrolled
April 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2028
August 30, 2023
August 1, 2023
9.8 years
January 23, 2018
August 28, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Frailty
Frailty defined by frailty phenotype measurement, according to Fried (Fried et al., 2011) definition.
10 years
Eligibility Criteria
HIV-positive patients who attend Infectious Diseases clinic at Prince of Wales Hospital
You may qualify if:
- HIV infection with positive anti-HIV antibody
- Age ≥50 years
You may not qualify if:
- Refuses to consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Prince of Wales Hospital
Shatin, Hong Kong
Related Publications (1)
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.
PMID: 11253156BACKGROUND
Biospecimen
Peripheral blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Grace Lui
CUHK
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Assistant Professor
Study Record Dates
First Submitted
January 23, 2018
First Posted
January 29, 2018
Study Start
April 1, 2018
Primary Completion (Estimated)
January 1, 2028
Study Completion (Estimated)
January 1, 2028
Last Updated
August 30, 2023
Record last verified: 2023-08