Determining Total Aromatic Amino Acid Requirements in Pregnant Women

NCT03409939 | Completed

• 1 other identifier: H17-02924
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

Phenylalanine and tyrosine are aromatic amino acids that people need to obtain in their diets. Amino acids are the building blocks for protein, are are therefore required to form tissues in the body. It is well known that pregnant women require more protein in their diets, but the exact amount for each amino acid is undetermined. To find out how much of phenylalanine and tyrosine pregnant women require, the investigators plan to study pregnant women in early and late gestation with a modern minimally invasive technique.

Conditions

Pregnancy Related

Keywords

nutrition; phenylalanine; tyrosine; stable isotope

Outcome Measures

Primary Outcomes (1)

• 13C Phenylalanine Oxidation

  Urine, breath and a single blood sample will be collected during the study to measure the rate of oxidation of 13C phenylalanine.

  8 hours

Study Arms (1)

Aromatic Amino Acid Intake

EXPERIMENTAL

Oral consumption of eight hourly experimental meals- Includes 4 tracer-free experimental meals containing a mixture of free amino acids, calories from a flavored liquid and protein free cookies and 4- labeled amino acid experimental meals.

Dietary Supplement: Aromatic Amino Acid Intake

Interventions

Aromatic Amino Acid Intake DIETARY_SUPPLEMENT

Intakes will be randomly chosen from a list of 8 doses of aromatic amino acids. Each intake will will be repeated approximately 4 times.

Aromatic Amino Acid Intake

Eligibility Criteria

• Age: 20 Years - 40 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• over the age of twenty
• under the age of forty
• in overall good health
• pregnant with a single child

You may not qualify if:

• Be under the age of twenty
• Be over the age of forty
• Be pregnant with more than one child
• Have a history of cardiovascular disease, endocrine disorders, or metabolic disorders
• Have recently lost a substantial amount of weight
• Have been pregnant with another child in the last 18 months
• Be substance dependent
• Be allergic to eggs
• Have severe nausea through the pregnancy
• Have gestational diabetes
• Have a history of spontaneous abortions
• Have had an unhealthy pre-pregnancy body mass index

Sponsors & Collaborators

• University of British Columbia: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Clinical Research and Evaluation Unit

Vancouver, British Columbia, V6H3N1, Canada

Location

Study Officials

• Rajavel Elango, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 18, 2018
• First Posted: January 24, 2018
• Study Start: February 1, 2018
• Primary Completion: January 17, 2020
• Study Completion: January 17, 2020
• Last Updated: September 23, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)