Substrate Metabolism During Exercise Following Ingestion of Ethanol

NCT03404947 | Completed

• 1 other identifier: ETOH-hs565
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate how ethanol (pure alcohol) influences carbohydrate and fat metabolism during prolonged, moderate intensity exercise. Participants will perform two bouts of cycling exercise with or without prior ingestion of ethanol, in a randomised order, separated by one week.

Conditions

Exercise Metabolism Following Ethanol Ingestion

Keywords

Exercise; Metabolism; Nutrition

Outcome Measures

Primary Outcomes (3)

• Change in muscle glycogen content

  Muscle biopsy and subsequent biochemical analysis

  Change in muscle glycogen content over 2 hours of moderate intensity cycling exercise

• Blood glucose concentration

  Venous blood samples will be taken and biochemically analysed for blood glucose concentration.

  Blood samples will be taken every 15 minutes during rest and the first hour of exercise, they will be taken every 30 minutes in the second hour of exercise.

• Blood non-esterified fatty acid (NEFA) concentration

  Venous blood samples will be taken and biochemically analysed for NEFA concentration.

  Blood samples will be taken every 15 minutes during rest and the first hour of exercise, they will be taken every 30 minutes in the second hour of exercise.

Secondary Outcomes (4)

• Blood ethanol concentration

  Blood samples will be taken every 15 minutes during rest and the first hour of exercise, they will be taken every 30 minutes in the second hour of exercise.

• Blood lactate concentration

  Blood samples will be taken every 15 minutes during rest and the first hour of exercise, they will be taken every 30 minutes in the second hour of exercise.

• Carbohydrate Oxidation

  Expired breath samples will be collected at baseline before beverage consumption and again after 1 hours rest. Samples will collected every 15 minutes during the first hour of exercise and every 30 minutes during the second hour

• Fat Oxidation

  Expired breath samples will be collected at baseline before beverage consumption and again after 1 hours rest. Samples will collected every 15 minutes during the first hour of exercise and every 30 minutes during the second hour

Study Arms (2)

Ethanol

EXPERIMENTAL

Participants will ingest ethanol (in the form of 40% ethanol) at an ingestion rate of 0.1 grams/kg lean body mass/hour in a solution with water.

Dietary Supplement: Ethanol

No Ethanol

NO INTERVENTION

Participants will ingest a volume matched beverage of water only.

Interventions

Ethanol DIETARY_SUPPLEMENT

For one exercise session, participants will be asked to ingest a quantity of ethanol (in the form of vodka) sufficient to maximally stimulate liver alcohol metabolism.

Ethanol

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Habitual alcohol consumer (average 1-14 units per week)
• BMI 18.5 - 29.9 kg/m2
• Be able to attend the laboratory and willing to participate in necessary protocols
• Be willing to undertake the durations of the exercise protocol (2 hours) \]
• Have the capacity and willingness to provide informed consent (oral and written)

You may not qualify if:

• Non-or excessive alcohol drinkers (0 or \>14 units per week)
• History of substance abuse
• Habitual/previously habitual smokers
• BMI \>30.0 kg/m2
• Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride)

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

University of Bath

Bath, Somerset, BA2 7AY, United Kingdom

Location

Related Publications (3)

• Jorfeldt L, Juhlin-Dannfelt A. The influence of ethanol on human splanchnic and skeletal muscle metabolism during exercise. Scand J Clin Lab Invest. 1977 Nov;37(7):609-18. doi: 10.3109/00365517709100653. No abstract available.

  PMID: 594641 BACKGROUND

• Juhlin-Dannfelt A, Ahlborg G, Hagenfeldt L, Jorfeldt L, Felig P. Influence of ethanol on splanchnic and skeletal muscle substrate turnover during prolonged exercise in man. Am J Physiol. 1977 Sep;233(3):E195-202. doi: 10.1152/ajpendo.1977.233.3.E195. No abstract available.

  PMID: 910908 BACKGROUND

• Juhlin-Dannfelt A, Jorfeldt L, Hagenfeldt L, Hulten B. Influence of ethanol on non-esterified fatty acid and carbohydrate metabolism during exercise in man. Clin Sci Mol Med. 1977 Sep;53(3):205-14. doi: 10.1042/cs0530205. No abstract available.

  PMID: 913043 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Ethanol

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Alcohols; Organic Chemicals

Study Officials

• Harry Smith

  University of Bath

  PRINCIPAL INVESTIGATOR

• James Betts, PhD

  University of Bath

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 5, 2017
• First Posted: January 19, 2018
• Study Start: November 13, 2017
• Primary Completion: June 29, 2018
• Study Completion: June 29, 2018
• Last Updated: March 6, 2019

Record last verified: 2019-03

Locations

GB (1)