The Acute Effects of Caffeine on Exercise and Cognition

NCT03400423 | Completed Phase 4 DMC

• 1 other identifier: Acute Exercise and Caffeine
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The effects of moderate intensity aerobic exercise and caffeine ingestion on cognition (more specifically working memory) in non-caffeine drinker and caffeine drinkers will be examined. The non-caffeine drinkers will be recruited for two visits, whereas, the caffeine drinkers will be recruited for three visits. The study involves a baseline assessment of cognition and examines the effects of exercise and caffeine. Finally the caffeine group will consist of a baseline and intervention assessment when deprived of caffeine (overnight abstinence). The exercise intervention is to complete 20-minutes of moderate intensity exercise (brisk walk) while the caffeine condition is to consume 1.2 mg/kg of caffeine. Immediately following both intervention the n-back assessment will be conducted.

Conditions

Adult Population

Keywords

Caffeine; Caffeine Withdrawal; Acute Aerobic Exercise; Cognition; Working Memory

Outcome Measures

Primary Outcomes (1)

• 3-back on the N-back task

  Participants will be instructed to click the left button of a computer mouse as soon as a target appears, and to keep in mind both the speed and accuracy components of the task. In the 1-back condition, the target is defined as a letter flashing that is the same as the one preceding it. For example, "x, interstimulus, x" would be the target. In the 2-back condition, the target is defined as a letter appearing that is the same as what preceded it 2 letters before. For example, "a, interstimulus, b, interstimulus, a", would be the target. In the 3-back condition, the target is defined as a letter appearing that is the same as what preceded it 3 letters before. For example, "a, interstimulus, b, interstimulus, c, interstimulus, a", would be the target. All tasks call into action the participant's working memory abilities, as a measure of cognition.

  Approximately 5 minutes

Secondary Outcomes (1)

• 0,1, and 2 back on the N-back task

  Approximately 15 minutes

Study Arms (6)

Non-caffeine exercise

EXPERIMENTAL

Exercise cognition score

Behavioral: Moderate Intensity Exercise

Non-caffeine cognition

ACTIVE COMPARATOR

Caffeine cognition score

Drug: Caffeine

Caffeine consumption exercise

EXPERIMENTAL

Exercise cognition score

Behavioral: Moderate Intensity Exercise

Caffeine consumption cognition

ACTIVE COMPARATOR

Caffeine cognition score

Drug: Caffeine

Deprived Caffeine consumers exercise

EXPERIMENTAL

Exercise cognition score

Behavioral: Moderate Intensity Exercise

Deprived caffeine consumers cognition

ACTIVE COMPARATOR

Caffeine administration cognition score

Drug: Caffeine

Interventions

Caffeine DRUG

Oral administration of 1.2mg/kg of powdered caffeine with water.

Caffeine consumption cognition; Deprived caffeine consumers cognition; Non-caffeine cognition

Moderate Intensity Exercise BEHAVIORAL

Moderate intensity exercise conducted on a treadmill. Moderate intensity exercise defined as (220-age)\*0.6.

Caffeine consumption exercise; Deprived Caffeine consumers exercise; Non-caffeine exercise

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Are over the age of 18 years (male or female)
• Do not consume more than 100 mg of caffeine a week
• Do not have any cognitive problems
• Are not pregnant
• Do not have a medical condition that prevents you to exercise
• Do not have an orthopaedic limitation
• Have access to a telephone or an email account for communication
• Can read and write in English You are being invited to take part in phase 2 and 3 of this research study because
• Are over the age of 18 years old
• Are consuming at least 150 mg of caffeine a day
• Do not have any cognitive problems
• Are not pregnant
• Do not have a medical condition that prevents you to exercise
• Do not have an orthopaedic limitation
• Have access to a telephone or an email account for communication

You may not qualify if:

• Potential subjects will be excluded if they are pregnant. Additionally, participants taking prescription medication for depression or anxiety, and participants that cannot give informed consent will be excluded.

Sponsors & Collaborators

• Western University, Canada: lead

Study Sites (1)

Western University

London, Ontario, Canada

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 9, 2018
• First Posted: January 17, 2018
• Study Start: February 1, 2018
• Primary Completion: June 1, 2019
• Study Completion: August 1, 2019
• Last Updated: March 4, 2024

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)