Regulation of Retinal Bloodflow Pressure
Regulation of Retinal Blood Flow in Response to an Experimental Increase in Intraocular Pressure
1 other identifier
observational
17
1 country
1
Brief Summary
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of ocular perfusion pressures. Large scale studies have shown that reduced ocular perfusion pressure is an important risk factor for the prevalence, the incidence and the progression of primary open angle glaucoma. There is also evidence that autoregulation is impaired in patients with primary open angle glaucoma. To gain more insight into these phenomena in humans is the primary goal of the present study. The present study aims to investigate the pressure/flow relationship as a measure for retinal blood flow autoregulation during an experimental increase in intraocular pressure by the use of the suction cup technique. Retinal blood flow will be measured by Doppler OCT.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Mar 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 8, 2018
CompletedFirst Posted
Study publicly available on registry
January 12, 2018
CompletedStudy Start
First participant enrolled
March 29, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2018
CompletedAugust 20, 2019
August 1, 2019
9 months
January 8, 2018
August 19, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Retinal pressure-flow-relationship as assessed with FDOCT
01.02.2018-31.12.2018
Eligibility Criteria
16 healthy subjects
You may qualify if:
- Men and women aged between 18 and 35 years
- Non-smokers
- Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropy \< 1 Dpt.
You may not qualify if:
- Treatment in the previous 3 weeks with any drug (except contraceptives)
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Blood donation during the previous 3 weeks
- Pregnancy, planned pregnancy or lactating
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Gerhard Garhoferlead
Study Sites (1)
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, A-1090, Austria
Related Publications (1)
Puchner S, Schmidl D, Ginner L, Augustin M, Leitgeb R, Szegedi S, Stjepanek K, Hommer N, Kallab M, Werkmeister RM, Schmetterer L, Garhofer G. Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):33. doi: 10.1167/iovs.61.2.33.
PMID: 32084274DERIVED
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assoc.Prof.PD, MD
Study Record Dates
First Submitted
January 8, 2018
First Posted
January 12, 2018
Study Start
March 29, 2018
Primary Completion
December 31, 2018
Study Completion
December 31, 2018
Last Updated
August 20, 2019
Record last verified: 2019-08