Müller's Muscle as a New Proprioceptive Organ

NCT03396627 | Unknown

• 1 other identifier: 4384-17-SMC
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives: Upper eyelid retraction was believed to be maintained solely by voluntary contraction of the levator palpebrae superioris (LPS) and frontalis muscles, together with involuntary contraction of the sympathetically innervated Müller's muscle (MM). However, several studies have suggested that the LPS also undergoes involuntary contractions, and that a visual stimulus may not be the only trigger for frontalis muscle contractions. Recent studies hypothesized that the MM contains proprioceptive neuronal structures, which elicit involuntary LPS muscle contraction by the mesencephalic trigeminal nucleus via a continuous stretch reflex. We aim to identify proprioceptive structures in MM by means of histological examinations. Methodology: Prospective study. Collaboration of oculoplastics, ophthalmologists and a neuroanatomy specialist in Sheba Medical Center. 50 fresh MM specimens from patients undergoing Müllerectomies will undergo histologic examinations, including immunohistochemical staining and light and electron microscopy. Significance: Identification of proprioceptive structures in MM will be the first evidence-based proof of a proprioceptive mechanism in the eyelid. This might have a significant impact on future surgical management of eyelid procedures. Comprehensive understanding of the mechanisms underlying eyelid function is especially important in the management of children with ptosis who may have coexisting amblyopia.

Conditions

Eyelid Movement Disorders; Eyelid Ptosis Congenital

Keywords

eyelid; Muller

Outcome Measures

Primary Outcomes (1)

• presence of proprioceptive organs in the muller muscle

  presence of proprioceptive organs in the muller muscle

  2 years

Study Arms (1)

muller muscle

muller muscle and conjunctiva excised during muller muscle conjunctival resection

Diagnostic Test: pathological examination

Interventions

pathological examination DIAGNOSTIC_TEST

fresh MM specimens from patients undergoing Müllerectomies will undergo histologic examinations

muller muscle

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients over 18 years old undergoing Müllerectomies

You may qualify if:

• specimens from patients undergoing Müllerectomies

You may not qualify if:

• small specimens (\<1 cm length and width)

Sponsors & Collaborators

• Sheba Medical Center: lead

Study Sites (1)

Sheba_Medical_Center

Ramat Gan, 52621, Israel

Location

Related Publications (1)

• Ben Simon GJ, Blaydon SM, Schwarcz RM, Nakra T, Goldberg RA, McCann JD. Paradoxical use of frontalis muscle and the possible role of botulinum a toxin in permanent motor relearning. Ophthalmology. 2005 May;112(5):918-22. doi: 10.1016/j.ophtha.2005.01.004.

  PMID: 15878076 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

specimens of muller muscle

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head, oculoplastic unit

Study Record Dates

• First Submitted: January 5, 2018
• First Posted: January 11, 2018
• Study Start: January 15, 2018
• Primary Completion: January 15, 2020
• Study Completion: January 15, 2021
• Last Updated: January 11, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)