The Intersectional Viborg Screening Program: Cost-(Effectiveness) of Screening for Diabetes and Cardiovascular Diseases

NCT03395509 | Enrolling By Invitation DMC

• 1 other identifier: VISP-dk
• Study Type: observational
• Target: 4,500
• Locations: 1 country
• Sites: 1

Brief Summary

This is an intersectional and interdisciplinary screening program in Viborg Municipality, including 67 years old citizens. This observational study will estimate the cost-effectiveness of a combined screening program for the following conditions: Abdominal aortic aneurysm, peripheral arterial disease, carotid plaque, hypertension, arrhythmia, and type-2-diabetes. Furthermore, the incidence of the outlined conditions will be described and so will the result of the intervention initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.)

Conditions

Aging; Aortic Aneurysm, Abdominal; Hypertension; Mass Screening; Peripheral Arterial Disease; Arrythmia; Diabetes; Carotid Atherosclerosis

Keywords

Mass screening; cardiovascular disease; diabetes

Outcome Measures

Primary Outcomes (6)

• Baseline prevalence of peripheral arterial disease (PAD) in men and women aged 67 years from a population screening study on the Municipal of Viborg.

  Ankel Brachial Index

  Inclusion will take place from sep. 2014 to sep. 2020

• Baseline prevalence of abdominal aortic aneurysm (AAA)

  Ultra sound examination (AP diameter (mm))

  Inclusion will take place from sep. 2014 to sep. 2020

• Baseline prevalence of diabetes

  Bedside HbA1c

  Inclusion will take place from sep. 2014 to sep. 2020

• Baseline prevalence of hypertension

  BP(mmhg)

  Inclusion will take place from sep. 2014 to sep. 2020

• Baseline prevalence of cardiac arrythmia

  ECG

  Inclusion will take place from sep. 2014 to sep. 2020

• Baseline prevalence of carotic plaques

  Ultra sound examination of A. carotis (IMT in mm)

  Inclusion will take place from sep. 2014 to sep. 2020

Secondary Outcomes (1)

• The cost(-effectiveness) of the screening program

  5 years after ending inclusion

Eligibility Criteria

• Age: 67 Years - 67 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Viborg municipality citizen are invited to the combined screening program around there 67th birthday. Participants with positive screening results are offered following up consultations and prophylactic interventions are initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.) 67 years-old citizens from the surrounding municipalities without the offer of the combined screening are used as a control group (1 case: 5 controls).

You may qualify if:

• All Viborg municipality citizen are invited to the combined screening program around there 67th birthday.

Sponsors & Collaborators

• Central Jutland Regional Hospital: lead
• Odense University Hospital: collaborator

Study Sites (1)

Cardiovascular research Center (KVC), Viborg Hospital

Viborg, 8800, Denmark

Location

Related Publications (5)

• Van Der Giessen D, Hogh A, Svenstrup D, Lindholt JS, Dahl M. Clinical relevance of screening for ECG abnormalities in 67-year-old Danes: a population-based cohort study from the Viborg Screening Programme (VISP). BMJ Open. 2025 Dec 23;15(12):e104169. doi: 10.1136/bmjopen-2025-104169.

  PMID: 41436274 DERIVED

• Gras Hojgaard H, Hogh AL, Lindholt JS, Frederiksen K, Dahl M. Effect of nurse-led telephone follow-up to optimize adherence to preventive medication after screen-detected cardiovascular disease: a randomized controlled trial. Eur J Cardiovasc Nurs. 2025 Jul 21;24(5):748-759. doi: 10.1093/eurjcn/zvaf047.

  PMID: 40130283 DERIVED

• Andersen JW, Hogh A, Lindholt JS, Sogaard R, Stovring H, Yderstraede KB, Sandbaek A, Dahl M. Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort. Clin Epidemiol. 2025 Feb 5;17:75-85. doi: 10.2147/CLEP.S487825. eCollection 2025.

  PMID: 39926308 DERIVED

• Dahl M, Andersen JW, Lindholt J, Krarup NT, Borregaard B, Uberg N, Hogh A. Prevalence of interarm blood pressure difference is notably higher in women; the Viborg population-based screening program (VISP). BMC Public Health. 2024 Jul 12;24(1):1868. doi: 10.1186/s12889-024-19388-8.

  PMID: 38997668 DERIVED

• Hogh A, Lindholt JS, Sogaard R, Refsgaard J, Svenstrup D, Moeslund NJ, Bredsgaard M, Dahl M. Protocol for a cohort study to evaluate the effectiveness and cost-effectiveness of general population screening for cardiovascular disease: the Viborg Screening Programme (VISP). BMJ Open. 2023 Feb 28;13(2):e063335. doi: 10.1136/bmjopen-2022-063335.

  PMID: 36854592 DERIVED

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Hypertension; Peripheral Arterial Disease; Arrhythmias, Cardiac; Diabetes Mellitus; Carotid Artery Diseases; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Aortic Diseases; Atherosclerosis; Arteriosclerosis; Arterial Occlusive Diseases; Peripheral Vascular Diseases; Heart Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Annette Høgh, MD, PhD

  Steering Committee

  STUDY CHAIR

• Marie Dahl, MSc(nurse)

  Steering Committee

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Associated professor

Study Record Dates

• First Submitted: March 15, 2017
• First Posted: January 10, 2018
• Study Start: August 1, 2014
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2029
• Last Updated: February 1, 2024

Record last verified: 2024-01

Locations

DK (1)