NCT03394248

Brief Summary

The purpose of this study is to determine early detection of concussion for those at risk of developing symptoms and to be able to detect subconcussive cerebral impairment, and thus gaining a better understanding of the injury patterns for concussions in Men's and Women's Collegiate sports.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 2018

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 20, 2017

Completed
20 days until next milestone

First Posted

Study publicly available on registry

January 9, 2018

Completed
17 days until next milestone

Study Start

First participant enrolled

January 26, 2018

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 3, 2018

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 13, 2020

Completed
Last Updated

April 14, 2022

Status Verified

April 1, 2022

Enrollment Period

5 months

First QC Date

December 20, 2017

Last Update Submit

April 7, 2022

Conditions

Keywords

Subconcussive head injury

Outcome Measures

Primary Outcomes (1)

  • Changes in cognition secondary to impact

    A mouthguard with built in sensors to collect data above the predetermined acceleration thresholds. The predetermined threshold for acceleration will be set to 5G in order to collect more data about subconcussive impacts, in addition to concussive impacts

    5 months

Secondary Outcomes (3)

  • ImPACT Testing

    5 months

  • King-Devick Test

    5 months

  • C3 Logix

    5 months

Interventions

The mouthguard will be used by athletes to measure the magnitude and number of impacts throughout one season.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Subjects for this study will be members of the NYIT Athletic Teams.

You may qualify if:

  • Subject is at least 18 years age and younger than 50 years of age
  • Subject experiences at least 8Gs of force on at least one occasion, as measured by accelerometer

You may not qualify if:

  • The subject suffered from any of the following at the time of event leading to a concussion:
  • Loss of consciousness \>2 minutes in the field as reported by witness
  • Seizures
  • Intractable vomiting
  • Paralysis
  • The subject has been diagnosed with an underlying neurodegenerative condition that may confound test results (e.g. Parkinson's Disease, Alzheimer's Disease)
  • The subject has a current or previous spinal cord injury
  • The subject is unable to complete assessment tools
  • The subject is pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

New York Institute of Technology

Old Westbury, New York, 11568, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Saliva

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemWounds and Injuries

Study Officials

  • Matthew Heller, D.O

    New York Institute of Technology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor, Family Medicine

Study Record Dates

First Submitted

December 20, 2017

First Posted

January 9, 2018

Study Start

January 26, 2018

Primary Completion

July 3, 2018

Study Completion

March 13, 2020

Last Updated

April 14, 2022

Record last verified: 2022-04

Locations