NCT03390140

Brief Summary

The primary goal of this study is to conduct a multi-site RCT to evaluate the replicability and efficacy of the ReInventing Yourself after SCI intervention in improving health and function outcomes for persons with spinal cord injury (SCI). A total of 252 participants will be randomized to one of three research arms: 1) Group treatment plus workbook (Group), 2) individual self-study through YouTube video plus workbook (Indiv), and 3) no treatment, no workbook (Control). Participants randomized to the Group arm will attend 6 virtual weekly group sessions led by a pair of group facilitators and will utilize the study workbook. Indiv arm participants will receive the workbook and will be instructed to independently access YouTube videos of the group session content. Control arm participants will not receive any intervention during the 6 week period. Participants in all three arms will be assessed at identical time points throughout the study: baseline, 6 weeks, 14 weeks, 22 weeks, 30 weeks, and 46 weeks. It is hypothesized that individuals in the Group intervention arm will show greater improvements after the six week intervention in SCI-specific and general self-efficacy, emotional well-being, increased societal participation, less depressive and anxiety symptomatology, and improved resilience than participants in the Indiv and Control arms.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
281

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2018

Longer than P75 for not_applicable

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 27, 2017

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 4, 2018

Completed
7 months until next milestone

Study Start

First participant enrolled

July 22, 2018

Completed
4.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2023

Completed
Last Updated

June 3, 2022

Status Verified

June 1, 2022

Enrollment Period

4.6 years

First QC Date

December 27, 2017

Last Update Submit

June 2, 2022

Conditions

Keywords

Spinal Cord InjuriesGroup InterventionSelf Efficacy

Outcome Measures

Primary Outcomes (1)

  • Moorong Self-Efficacy Scale (MSES) - assessing change over time

    The MSES is a 16 item self-report measure of self-efficacy related to everyday life activities, designed specifically for persons with SCI. Individuals use a 7-point Likert scale ranging from 1 (very uncertain) to 7 (very certain) to rate their ability to perform 16 everyday tasks, with higher scores representing greater perceived self-efficacy. A Total Score, ranging from 16 to 112 is calculated by summing all item responses

    The MSES will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

Secondary Outcomes (6)

  • Generalized Self-Efficacy Scale (GSES)- assessing change over time

    The GSES will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

  • Diener Satisfaction with Life Scale (SWLS)- assessing change over time

    The SWLS will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

  • Participation Assessment with Recombined Tools - Objective (PART-O)- assessing change over time

    The PART-O will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

  • Patient Health Questionnaire - 9 (PHQ-9)- assessing change over time

    The PHQ-9 will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

  • General Anxiety Disorder 7-item (GAD-7)- assessing change over time

    The GAD-7 will be administered at baseline and subsequent follow-up assessments (i.e., 6 weeks, 14 weeks, 22 weeks, 30 weeks, 46 weeks)

  • +1 more secondary outcomes

Study Arms (3)

Group

EXPERIMENTAL

ReInventing Yourself after SCI structured group CBT and ReInventing Yourself after SCI study-specific workbook

Behavioral: ReInventing Yourself after SCI structured group CBTBehavioral: ReInventing Yourself after SCI study-specific workbook

Indiv

ACTIVE COMPARATOR

ReInventing Yourself after SCI study-specific workbook and ReInventing Yourself after SCI YouTube videos

Behavioral: ReInventing Yourself after SCI study-specific workbookBehavioral: ReInventing Yourself after SCI YouTube videos

Control

NO INTERVENTION

No group sessions, no YouTube videos, no workbook

Interventions

A study-specific workbook that incorporates positive psychotherapy concepts to develop optimistic self-efficacy beliefs, thereby strengthening resilience to emotional distress, enhancing a sense of well-being and promoting a more active lifestyle.

GroupIndiv

ReInventing Yourself after SCI intervention integrates positive psychotherapy concepts into structured group cognitive behavioral therapy (CBT) to develop optimistic self-efficacy beliefs, thereby strengthening resilience to emotional distress, enhancing a sense of well-being and promoting a more active lifestyle. The intervention consists of six weekly two-hour facilitator-led sessions that include didactic presentations of eight core skills and related experiential exercises with extensive group discussion.

Group

YouTube videos containing the content of the ReInventing Yourself after SCI structured group CBT sessions

Indiv

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • History of spinal cord injury/disorder (SCI/D) at any neurological level
  • At least 4 weeks post-discharge from initial inpatient rehabilitation
  • English speaking in order to complete study measures and participate in group interactions
  • Access to the internet and a laptop/desktop computer/smartphone with webcam and the ability and willingness to download Zoom software to join a video conference
  • Able to provide informed consent to participate.

You may not qualify if:

  • Diagnosed with MS, Lupus, ALS, or Spina Bifida
  • History of moderate or severe traumatic brain injury
  • Current participation in another RCT
  • Unable to verbally communicate
  • Unable to attend group sessions
  • Active participation in another formal clinical group or psychological therapy
  • Currently experiencing moderately severe or greater levels of depressive symptoms which would require more intense treatment than is provided in this intervention, as evidenced by a score of 15 or higher on the PHQ-9
  • Has any medical or psychological condition that, in the judgment of the investigators, precludes successful participation in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Craig Hospital

Englewood, Colorado, 80113, United States

Location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

Kessler Foundation

West Orange, New Jersey, 07052, United States

Location

MeSH Terms

Conditions

Spinal Cord Injuries

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesTrauma, Nervous SystemWounds and Injuries

Study Officials

  • Susan Charlifue, PhD

    Craig Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 27, 2017

First Posted

January 4, 2018

Study Start

July 22, 2018

Primary Completion

March 1, 2023

Study Completion

March 1, 2023

Last Updated

June 3, 2022

Record last verified: 2022-06

Locations