Preoperative Epidural Labor Analgesia and Postoperative Pain

NCT03381690 | Completed

• 1 other identifier: Csec postop pain
• Study Type: observational
• Target: 222
• Locations: 1 country
• Sites: 1

Brief Summary

Parturients who undergo emergency Cesarean section (C-sec) after experiencing labor pain are likely to develop pain-induced central sensitization. The investigators hypothesized that those without epidural labor analgesia undergoing subsequent emergency C-sec would experience more severe postoperative pain or require more analgesia after C-sec compared to those with epidural labor analgesia. Thus, the investigators conducted this retrospective study by grouping parturients undergoing emergency C-sec after experiencing labor pain into two groups (epidural labor group and no epidural labor group) and those undergoing elective C-sec aimed to compare the effect of epidural labor analgesia on postoperative pain severity and analgesic consumption.

Conditions

Cesarean Section

Outcome Measures

Primary Outcomes (1)

• The change of numerical rating scale for postoperative pain

  At postoperative 6h, 24h, 48h, and 72h.

Secondary Outcomes (1)

• The change of postoperative analgesic consumption

  At postoperative 6h, 24h, 48h, and 72h.

Study Arms (3)

Epidural (ED) emergent C-sec

Procedure: Epidural labor analgesia

Non-ED emergent C-sec

Non-ED elective C-sec

Interventions

Epidural labor analgesia PROCEDURE

Epidural catheter was inserted for labor analgesia using an 18-gauge Tuohy needle and a 20 gauge epidural catheter. In our institute, for epidural labor analgesia, 10 ml bolus of 0.075% levobupivacaine mixed with fentanyl 2 μg/ml was administered and same regimen was continuously infused by patient-controlled epidural analgesia (infusion rate : 10 ml/hr, bolus : 4 ml, lockout time: 30 min).

Epidural (ED) emergent C-sec

Eligibility Criteria

• Age: 20 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients underwent elective or emergent Cesarean section.

You may qualify if:

• Cesarean section(C-sec) under spinal anesthesia

You may not qualify if:

• Patients without accurate medical records
• Failure of epidural analgesia

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: October 24, 2017
• First Posted: December 22, 2017
• Study Start: September 1, 2017
• Primary Completion: August 31, 2018
• Study Completion: August 31, 2018
• Last Updated: November 22, 2019

Record last verified: 2019-11

Locations

KR (1)