Vitamin D and Hand Grip Strength at 5 Years in Odense Child Cohort

NCT03381378 | Completed DMC

• 1 other identifier: VITHGS
• Study Type: observational
• Target: 881
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will encompass an analysis of an eventual association between vitamin D status (maternal during pregnancy, at birth or at 5 years) and hand grip strength at 5 years in children from Odense Child Cohort. Odense Child Cohort is a large-scale, prospective, population-based, follow-up study. Mothers and their children born from January 2010 to December 2012 and resident in the Municipality of Odense, Denmark, are followed from early pregnancy up to adulthood. Data is obtained from questionnaires and medical records and venous blood samples were drawn and stored at a biological bank. Low muscle strength in children has been linked to adiposity, cardiovascular disease and metabolic risk factors and low muscle strength in adolescence has been shown to be a risk factor of early adulthood mortality. There are not many studies on muscle strength in small children. There is some evidence of vitamin D concentrations in the blood having a positive correlation to upper body muscle strength in adolescent girls. Hypovitaminosis D defined as serum 25-hydroxyvitamin D \<50nmol/L was evident in 27,8% of the pregnant women and 47,7% of the new-born children in Odense Child Cohort. Animal studies have shown an effect of vitamin D on regulation of muscle function and development. Studies on humans adults have shown that vitamin D deficiency can lead to myopathy. Myopathy in children as a result of hypovitaminosis D is not well-studied. Given the high prevalence of hypovitaminosis D, mild or severe vitamin D-associated myopathy may be prevalent in preschool children. The objectives of this study are 1) to create reference values and determine predictors of hand grip strength at five years, 2) to analyze the associations between vitamin D at different time points and hand grip strength at 5 years.

Conditions

Hypovitaminosis D; Hand Grasp; Children

Keywords

Vitamin D; s-25-hydroxyvitamin D; hand grip strength; myopathy; muscle

Outcome Measures

Primary Outcomes (1)

• Hand Grip Strength at 5 years

  DHD-1 Digital Hand Dynamometer is used to measure 5-year-old children's hand grip strength. According to standard protocol the child is instructed to hold the dynamometer and the handle is adjusted to the child's hand. The child must be able to press the handle using the whole hand and not just the finger joints. The child must sit with a straight back and feet on the ground. The arm must not be supported by the hip, the elbow must be flexed to 90 degrees and the hand must be in the natural position. The child is instructed to press as hard as possible but in a slow movement to avoid sudden changes in position that might affect the results. Each measurement is approximately 5 seconds long with 1 minute break in between measuring the right and left hand interchangeably. Three measurements of each hand are taken starting with the right hand. If the last measure is the highest, a fourth measurement is taken and a fifth and last measurement is taken if the fourth is the highest.

  Examination within a week of 5 year birthday. 3-5 measurements with a duration of 5 seconds each of each hand.

Eligibility Criteria

• Age: 5 Years - 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This study was conducted using data from the Odense Child Cohort. Mothers and their children born from January 2010 to December 2012 and resident in the Municipality of Odense, Denmark, were followed from early pregnancy up to five years at present. Approximately 2500 children were included.

You may qualify if:

• year-old children participating in Odense Child Cohort.

You may not qualify if:

• Multiple and/or preterm birth (gestational age (GA) \<259 days)
• Chronic disease
• No available hand grip data at five years.

Sponsors & Collaborators

• Odense University Hospital: lead

Related Publications (4)

• Stark T, Walker B, Phillips JK, Fejer R, Beck R. Hand-held dynamometry correlation with the gold standard isokinetic dynamometry: a systematic review. PM R. 2011 May;3(5):472-9. doi: 10.1016/j.pmrj.2010.10.025.

  PMID: 21570036 BACKGROUND

• Andersen LB, Abrahamsen B, Dalgard C, Kyhl HB, Beck-Nielsen SS, Frost-Nielsen M, Jorgensen JS, Barington T, Christesen HT. Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study. Clin Endocrinol (Oxf). 2013 Sep;79(3):333-41. doi: 10.1111/cen.12147. Epub 2013 Jul 2.

  PMID: 23305099 BACKGROUND

• Lykkedegn S, Beck-Nielsen SS, Sorensen GL, Andersen LB, Fruekilde PBN, Nielsen J, Kyhl HB, Joergensen JS, Husby S, Christesen HT. Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort. Clin Nutr. 2017 Dec;36(6):1621-1627. doi: 10.1016/j.clnu.2016.10.008. Epub 2016 Oct 27.

  PMID: 27817876 BACKGROUND

• Kyhl HB, Jensen TK, Barington T, Buhl S, Norberg LA, Jorgensen JS, Jensen DF, Christesen HT, Lamont RF, Husby S. The Odense Child Cohort: aims, design, and cohort profile. Paediatr Perinat Epidemiol. 2015 May;29(3):250-8. doi: 10.1111/ppe.12183. Epub 2015 Mar 10.

  PMID: 25756293 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Venous blood samples.

MeSH Terms

Conditions

Vitamin D Deficiency; Muscular Diseases

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant, Professor, MD, PhD

Study Record Dates

• First Submitted: December 18, 2017
• First Posted: December 22, 2017
• Study Start: January 4, 2016
• Primary Completion: June 30, 2017
• Study Completion: June 30, 2017
• Last Updated: December 26, 2017

Record last verified: 2017-12