The Relationship Between Exercise Frequency, Intensity, and Restoration of Cardiometabolic Health

NCT03376685 | Completed

• 1 other identifier: 17-08-008
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Regular physical activity is well established to decrease the risk of cardiometabolic diseases. While research has characterized responses based on exercise intensity, many beneficial effects of exercise are transient in nature, and therefore exercise frequency may play an important, yet currently under-appreciated, role in improving health. The purpose of this study is to determine the efficacy of 6-week high-frequency endurance (END) or low-frequency sprint (SIT) training with respect to reducing clinically relevant cardiometabolic risk factors in overweight/obese males. It is hypothesized that END, performed at a greater frequency than SIT, will markedly improve cardiometabolic health, while low-frequency SIT will not.

Conditions

Overweight or Obesity

Keywords

Endurance training; Sprint interval training; Glycemic regulation; Lipid homeostasis; Cardiovascular health

Outcome Measures

Primary Outcomes (3)

• Cardiorespiratory fitness

  Assessed via VO2 peak test, to determine the change in cardiorespiratory fitness following 6-weeks of exercise training

  Baseline (pre-training) vs. week 6 (post-training)

• Free-living glycemic regulation

  Assessed via continuous glucose monitoring (CGM), to determine the change in free-living glycemic regulation following 6-weeks of exercise training

  Baseline (pre-training) vs. week 6 (post-training)

• Glucose tolerance

  Assessed via an oral glucose tolerance test (OGTT) to determine changes in standardized glycemic regulation following 6-weeks of exercise training

  Baseline (pre-training) vs. week 6 (post-training)

Secondary Outcomes (11)

• Blood lipids

  Baseline (pre-training) vs. week 6 (post-training)

• HbA1C

  Baseline (pre-training) vs. week 6 (post-training)

• Post-prandial blood lipids

  Baseline (pre-training) vs. week 6 (post-training)

• Blood pressure

  Baseline (pre-training) vs. week 6 (post-training)

• Body composition

  Baseline (pre-training) vs. week 6 (post-training)

Study Arms (2)

Endurance Exercise Training (END)

EXPERIMENTAL

This group is performing END training for 6 weeks in duration. Intervention: Behavioral: Endurance Exercise Training (END)

Behavioral: Endurance Exercise Training (END)

Sprint Exercise Training (SIT)

EXPERIMENTAL

This group is performing SIT training for 6 weeks in duration. Intervention: Behavioral: Sprint Exercise Training (SIT)

Behavioral: Sprint Exercise Training (SIT)

Interventions

Endurance Exercise Training (END) BEHAVIORAL

Physical activity will be conducted on cycle ergometers under supervision. Participants will exercise 5 days a week for 30 minutes (Week 1-2); 35 minutes (Weeks 3-4); or 40 minutes (Weeks 5-6) at 60% VO2 peak.

Endurance Exercise Training (END)

Sprint Exercise Training (SIT) BEHAVIORAL

Physical activity will be conducted on cycle ergometers under supervision. Participants will exercise 3 days a week involving a 3-minute warm-up, followed up 4 repetitions (Week 1-2); 5 repetitions (Weeks 3-4); or 6 (Weeks 5-6) repetitions of 30 seconds at a maximal intensity with 2 minutes' rest in between. Exercise will conclude with a 2-minute cool-down.

Sprint Exercise Training (SIT)

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male, aged 18-70 years
• Body mass index (BMI) \> 25 kg/m\^2 (classified as overweight or obese)
• Sedentary (\<100 minutes moderate physical activity per week)
• Approval for vigorous exercise via physical activity readiness questionnaire (PARQ+)

You may not qualify if:

• Prescribed with glucose lowering medications
• Smoker
• Not cleared for physical activity

Sponsors & Collaborators

• University of Guelph: lead

Study Sites (1)

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

Location

Related Publications (1)

• Petrick HL, King TJ, Pignanelli C, Vanderlinde TE, Cohen JN, Holloway GP, Burr JF. Endurance and Sprint Training Improve Glycemia and V O2peak but only Frequent Endurance Benefits Blood Pressure and Lipidemia. Med Sci Sports Exerc. 2021 Jun 1;53(6):1194-1205. doi: 10.1249/MSS.0000000000002582.

  PMID: 33315809 DERIVED

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jamie Burr, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

• Graham Holloway, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Jamie Burr, Director, Human Performance and Health Laboratory, Principal Investigator, Assistant Professor, PhD

Model Details: This study is a 6-week exercise training study, with two possible parallel training groups: endurance (END) or sprint (SIT) training.

Study Record Dates

• First Submitted: December 6, 2017
• First Posted: December 18, 2017
• Study Start: May 30, 2018
• Primary Completion: November 18, 2019
• Study Completion: November 18, 2019
• Last Updated: April 29, 2020

Record last verified: 2020-04

Locations

CA (1)