Reducing the Duration of Untreated Psychosis in the United States

NCT03369730 | Completed

• 2 other identifiers: GCO 17-0655R34MH115463
• Study Type: observational
• Target: 94
• Locations: 1 country
• Sites: 3

Brief Summary

The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP). The study team will evaluate the feasibility of screening a consecutive help-seeking population entering mental health services in order to facilitate early identification of FEP cases, rapid referral to specialty care and engagement in treatment.

Conditions

First Episode Psychosis (FEP); At Risk Mental State (ARMS)

Keywords

Screening; Duration of Untreated Psychosis (DUP); Coordinated Specialty Care (CSC); First Episode Psychosis (FEP); At Risk Mental State (ARMS); Clinical High Risk for Psychosis (CHR)

Outcome Measures

Primary Outcomes (1)

• Duration of Untreated Psychosis (DUP)

  The DUP is defined as the time, in weeks, between onset of psychotic symptoms and initiation of FEP treatment, in the case of this study, entry into Coordinated Specialty Care (CSC) programs for first episode psychosis (FEP).

  Day 1

Secondary Outcomes (5)

• Rate of completed PQ-B screen.

  Day 1

• Rate of completed SIPS

  Day 1

• Rates of FEP cases

  Day 1

• Rate of ARMS cases

  Day 1

• Rate of CHR cases

  Day 1

Eligibility Criteria

• Age: 12 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Individuals ages 12 to 30 entering child/adolescent and adult community mental health clinics.

You may qualify if:

• age 12- 30
• ability to participate in assessments in English
• ability to provide informed consent (assent for those under age 18)
• meet criteria for psychosis or psychosis risk on SIPS

You may not qualify if:

• previous diagnosis of schizophrenia or schizoaffective disorder.

Sponsors & Collaborators

• Icahn School of Medicine at Mount Sinai: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (3)

Trustees of Boston University

Boston, Massachusetts, 02215, United States

Location

Research Foundation/City University of New York (CUNY) on behalf of CUNY Graduate School

New York, New York, 10027, United States

Location

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States

Location

Related Publications (3)

• Addington J, Heinssen RK, Robinson DG, Schooler NR, Marcy P, Brunette MF, Correll CU, Estroff S, Mueser KT, Penn D, Robinson JA, Rosenheck RA, Azrin ST, Goldstein AB, Severe J, Kane JM. Duration of Untreated Psychosis in Community Treatment Settings in the United States. Psychiatr Serv. 2015 Jul;66(7):753-6. doi: 10.1176/appi.ps.201400124. Epub 2015 Jan 15.

  PMID: 25588418 BACKGROUND

• Dixon LB, Goldman HH, Bennett ME, Wang Y, McNamara KA, Mendon SJ, Goldstein AB, Choi CW, Lee RJ, Lieberman JA, Essock SM. Implementing Coordinated Specialty Care for Early Psychosis: The RAISE Connection Program. Psychiatr Serv. 2015 Jul;66(7):691-8. doi: 10.1176/appi.ps.201400281. Epub 2015 Mar 16.

  PMID: 25772764 BACKGROUND

• Rietdijk J, Klaassen R, Ising H, Dragt S, Nieman DH, van de Kamp J, Cuijpers P, Linszen D, van der Gaag M. Detection of people at risk of developing a first psychosis: comparison of two recruitment strategies. Acta Psychiatr Scand. 2012 Jul;126(1):21-30. doi: 10.1111/j.1600-0447.2012.01839.x. Epub 2012 Feb 15.

  PMID: 22335365 BACKGROUND

Study Officials

• Yulia Landa, PsyD, MS

  Icahn School of Medicine at Mount Sinai

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 6, 2017
• First Posted: December 12, 2017
• Study Start: February 19, 2018
• Primary Completion: September 15, 2021
• Study Completion: September 15, 2021
• Last Updated: December 14, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will share

Locations

US (3)