Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents

NCT03369691 | Completed

• 1 other identifier: 20173441
• Study Type: observational
• Target: 258
• Locations: 1 country
• Sites: 1

Brief Summary

The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females. A Hispanic/Latina cohort has recently been added with permission for the sponsor.

Conditions

Obesity, Adolescent; Stress; Physical Activity

Outcome Measures

Primary Outcomes (1)

• Comparison of food intake from buffet lunch after the control and stress sessions

  Randomize lab session to assign each participant to a non-stress or stress condition, and reversed in the next session. Ad-libitum food intake (amount of added sugar and solid fat) during both sessions will be measured and compared.

  7 days between the two sessions

Secondary Outcomes (3)

• Body mass index (BMI)

  1 hour

• Physical activity energy expenditure

  7 days

• Visceral fat percent

  1 hour

Eligibility Criteria

• Age: 13 Years - 17 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Community sample

You may qualify if:

• African-American, Hispanic, Non-Hispanic White females from 13-17 years old and Tanner Stage ≥III.
• BMI values will be balanced (1/3rd normal, 1/3rd overweight and 1/3rd obese range percentile BMI values) using Center for Disease Control criteria

You may not qualify if:

• Participants with a BMI below the normal range, trying to lose weight, on medications that affect appetite or hypothalamic-pituitary-adrenal axis, or with a history of bariatric surgery, will be excluded.
• Restrained or binge eaters, individuals who score below 50 on a 100 mm Visual Analog Scale for foods provided in the study, or those allergic to these foods will be excluded.
• Participants with major psychiatric disorders (e.g., anxiety, eating, mood, substance use disorders) or medical problems (e.g., endocrine disorders or unstable cardiac, pulmonary or renal conditions) will be excluded.
• Pregnant females, or those suspected of being pregnant, will be excluded.

Sponsors & Collaborators

• University of California, Irvine: lead

Study Sites (1)

Universty of California, Irvine

Irvine, California, 92617, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

saliva, serum, plasma and hair

MeSH Terms

Conditions

Pediatric Obesity; Motor Activity

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Uma Rao, MD

  University of California, Irvine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 1, 2017
• First Posted: December 12, 2017
• Study Start: December 16, 2017
• Primary Completion: February 7, 2026
• Study Completion: February 7, 2026
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)