Myocardial Infarction With Non-obstructive Coronary Arteries in Turkish Population

NCT03364387 | Completed

• 1 other identifier: MINOCA-TR
• Study Type: observational
• Target: 16,026
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to analyze the Demographics, Clinical Profiles, Management, in-Hospital and Long-Term Outcomes of Patients with Acute Coronary Syndrome Syndrome And Myocardial Infarction with Non-obstructive Coronary Artery Disease.

Conditions

Acute Coronary Syndrome; Myocardial Infarction; Atrial Fibrillation; Diabetes Mellitus

Keywords

Acute Coronary Syndrome; MINOCA; Myocardial Infarction; Atrial Fibrillation

Outcome Measures

Primary Outcomes (1)

• Composites of Myocardial Infarction, Hospitalization, Revascularization, Death

  Re-infarction, Any cause or Cardiovascular Hospitalization or Death

  12 months

Secondary Outcomes (2)

• Atrial Fibrillation

  12 months

• Heart failure

  12 months

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Study population will consisted patients with acute coronary syndrome undergoing invasive diagnostic coronary angiography. Patients will eligible to take part in the study if they will fulfilled the criteria for acute myocardial infarction.

You may qualify if:

• Patients older than 18 years
• Evidence of an MI as defined any one of the following criteria:
• Detection of a rise and/or fall of cardiac biomarker values \[preferably cardiac troponin (cTn)\] with at least one value above the 99th percentile upper reference limit (URL) and with at least one of the following:
• i. Symptoms of ischaemia. ii. New or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block (LBBB).
• iii. Development of pathological Q waves in the ECG. iv. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality.
• v. Identification of an intracoronary thrombus by angiography.
• Invasive diagnostic coronary angiography (IDCA) findings to allow determination of the presence /absence of obstructive coronary artery disease
• Signed informed consent form to trial participation

You may not qualify if:

• Inability/Refused to provide informed consent
• Age below 18 years
• Patients with unstable angina pectoris (ACS without increase and/or decrease of a cardiac biomarker, preferably high-sensitivity cardiac troponin, with at least one value above the 99th percentile of the upper reference limit)
• Patients refused invasive diagnostic coronary angiography
• Myocardial infarction associated with revascularization procedures

Sponsors & Collaborators

• Cardiovascular Academy Society, Turkey: lead

Study Sites (1)

Emin Alioğlu

Izmir, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Fasting venous blood sample

MeSH Terms

Conditions

Acute Coronary Syndrome; Myocardial Infarction; Atrial Fibrillation; Diabetes Mellitus; MINOCA

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Arrhythmias, Cardiac; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2017
• First Posted: December 6, 2017
• Study Start: March 5, 2018
• Primary Completion: May 15, 2018
• Study Completion: June 15, 2018
• Last Updated: July 24, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)