Conditioned Pain Modulation in Chronic Neck Pain Patients

NCT03362203 | Unknown

• 1 other identifier: Neckpainspine001
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.

Conditions

Neck Pain

Keywords

Conditioned pain modulation, neck pain

Outcome Measures

Primary Outcomes (1)

• Change of pressure pain threshold (PPT)

  A cold pressor test (CPT) was used to induce pain and trigger the conditioned pain modulation (CPM) response. The conditioned stimulus was immersion of the leg in a bucket of ice water on the side ipsilateral to the most painful neck region. The neck PPT was recorded beginning 30 s after immersion of the leg with two PPT measures for each point. The PPT will be also measured again immediately after CPT.

  The PPT will be measured before CPT, 30 seconds after the CPT begin, and immediately after CPT.

Secondary Outcomes (1)

• Numerical rating scale for pain (NRS)

  The patients used this scale to rate the pain intensity of the neck pain before the experiment.

Study Arms (2)

Patients with chronic neck pain

Patients,aged 21-80 years, must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.

Other: Patients with chronic neck pain

Subjects without chronic neck pain

Subjects,aged 21-80 years, must not have presented episodes of chronic neck pain for more than 7 days in the last 12 months.

Other: Subjects without chronic neck pain

Interventions

Patients with chronic neck pain OTHER

Patients,aged 21-80 years, must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.

Patients with chronic neck pain

Subjects without chronic neck pain OTHER

Subjects,aged 21-80 years, must not have presented episodes of chronic neck pain for more than 7 days in the last 12 months.

Subjects without chronic neck pain

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Chronic neck pain subjects People must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies. Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded. 2. Healthy volunteers These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.

You may qualify if:

• Age 21-80 years old.
• People must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.

You may not qualify if:

• Age under 21 or over 80.
• Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases.
• Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded.
• Healthy volunteers
• Age 21-80 years old.
• These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
• Age below 21 or over 80 years old.
• These participants have presented episodes of low back pain for more than 7 days in the last 12 months.

Sponsors & Collaborators

• Peking University People's Hospital: lead

Study Sites (1)

Peking University People's Hospital

Beijing, 100044, China

Location

Related Publications (3)

• Dailey DL, Rakel BA, Vance CGT, Liebano RE, Amrit AS, Bush HM, Lee KS, Lee JE, Sluka KA. Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain. 2013 Nov;154(11):2554-2562. doi: 10.1016/j.pain.2013.07.043. Epub 2013 Jul 27.

  PMID: 23900134 BACKGROUND

• Xia W, Morch CD, Matre D, Andersen OK. Exploration of conditioned pain modulation effect on long-term potentiation-like pain amplification in humans. Eur J Pain. 2017 Apr;21(4):645-657. doi: 10.1002/ejp.968. Epub 2016 Oct 20.

  PMID: 27766711 BACKGROUND

• Neziri AY, Dickenmann M, Scaramozzino P, Andersen OK, Arendt-Nielsen L, Dickenson AH, Curatolo M. Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients. Pain. 2012 Feb;153(2):311-318. doi: 10.1016/j.pain.2011.10.008. Epub 2011 Nov 17.

  PMID: 22100357 BACKGROUND

MeSH Terms

Conditions

Neck Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Chen Guo, Master

  Peking University People's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Weiwei Xia, Ph.D.

CONTACT

008613260001978; weiweixia2016@163.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Spine Surgery

Study Record Dates

• First Submitted: November 26, 2017
• First Posted: December 5, 2017
• Study Start: January 1, 2018
• Primary Completion: August 1, 2018
• Study Completion: August 1, 2018
• Last Updated: December 5, 2017

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)