The Relationship Between Physical Activity and Radiographic Osteoarthritis Worsening
1 other identifier
observational
1,200
0 countries
N/A
Brief Summary
Wuchuan Osteoarthritis Study is a population-based longitudinal study of natural history of knee osteoarthritis and its risk factors. At baseline and follow-up visits, IPA-Q questionnaire and a radiographs at tibiofemoral (TF) joints will be taken in order to assess the relationship between physical activity and radiographic osteoarthritis worsening.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2018
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 25, 2017
CompletedFirst Posted
Study publicly available on registry
November 30, 2017
CompletedStudy Start
First participant enrolled
January 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2020
CompletedNovember 30, 2017
November 1, 2017
3 years
November 25, 2017
November 25, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
worsening of radiographic osteoarthritis
The tibiofemoral radiograph of both knee joint will be taken at baseline and in 3 years. Knee radiographs will be read by one investigator according to Kellgren and Lawrence (K/L) criteria. A knee will be defined as ROA worsening if its K/L grade increased by at least 1 grade except for the change from 0 to 1 during follow-up.
3 years after enrollment
Secondary Outcomes (1)
The Western Ontario and McMaster Universities Osteoarthritis Index
3 years after enrollment
Study Arms (1)
Wuchuan residents
All residents that meet the criteria can be enrolled in this group, receiving a home interview (including IPA-Q to assess the level of physical activity) and a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints at baseline and 3 years later.
Interventions
According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.
Eligibility Criteria
People, over 50 years old, in a rural area in Northern China (Wuchuan, Inner Mongolia)
You may qualify if:
- people aged 50 or over
- Wuchuan permanent resident population
You may not qualify if:
- patients with rheumatoid arthritis
- the disabled
- patients with mental disorders
- laid up for malignant tumor
- people who live or work outside for more than half a year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jianhao Lin, MD
arthritis clinic and research center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- arthritis clinic and research center
Study Record Dates
First Submitted
November 25, 2017
First Posted
November 30, 2017
Study Start
January 1, 2018
Primary Completion
December 31, 2020
Study Completion
December 31, 2020
Last Updated
November 30, 2017
Record last verified: 2017-11
Data Sharing
- IPD Sharing
- Will not share