NCT03358160

Brief Summary

The aim of this study is to investigate the possible effects that a motor limitation at the peripheral level might have on the ability to visually discriminate others' actions. Previous literature has shown that specific motor skills (motor expertise) facilitate the visual discrimination of domain-specific actions, and that these motor experts' superior abilities might be mediated by areas not only responsible for the visual recognition of movements (as it happens in non-expert subjects) but also involved in motor planning. Similarly, impairment in the motor system due to neurological damage modulates not only the ability to perform movements but also the ability to discriminate and predict the temporal course of observed actions. Based on these findings, it has been hypothesized that the motor representations of gait, despite being a hyper-learned motor pattern, might be subjected to modification as a result of an impairment of walking caused by a peripheral functional limitation in the lower limbs as the one characterizing orthopaedic patients who underwent a surgical operation for total knee arthroprosthesis. In this protocol, patients are thus required to perform visual discrimination tasks based on the observation of movements performed with either the upper or lower limbs, and their performance is expected to correlated with their functional impairments in movement execution. These results would indicate that the (in)ability to perform a movement might have an impact on its representation at the central level and on internal motion simulation capabilities, which also influence the ability to visual discriminate others' actions through action-perception transfer: this would suggest that rehabilitation in orthopaedic patients should take into account (and restore) such a central impairment in motor representations.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2016

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 31, 2016

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2017

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

November 21, 2017

Completed
9 days until next milestone

First Posted

Study publicly available on registry

November 30, 2017

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2018

Completed
Last Updated

November 30, 2017

Status Verified

November 1, 2017

Enrollment Period

10 months

First QC Date

November 21, 2017

Last Update Submit

November 24, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Group Differences in action discrimination performance.

    Group Differences in action discrimination performance depending on the impairment in movement execution.

    End 2018.

Study Arms (3)

TKA

Orthopaedic patients who underwent surgical operation for total knee arthroprothesis.

Behavioral: Action discrimination tasks.

Rizoarthrosis

Orthopaedic patients who underwent surgical operation to treat chronic arthrosis of the thumb.

Behavioral: Action discrimination tasks.

Healthy Controls

Healthy age-matched controls.

Behavioral: Action discrimination tasks.

Interventions

The investigators will compare the groups' performance during action discrimination tasks related to movements of the upper vs. lower limbs.

Healthy ControlsRizoarthrosisTKA

Eligibility Criteria

Age45 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Orthopaedic patients and age-matched healthy controls.

You may qualify if:

  • Participants must be able to understand instructions and have no history of neurological or psychiatric disorders.

You may not qualify if:

  • History of neurological or psychiatric disorders.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

IRCCS Galeazzi Orthopedic Hospital

Milan, 20161, Italy

RECRUITING

MeSH Terms

Conditions

Musculoskeletal DiseasesMotor DisordersPerceptual Disorders

Condition Hierarchy (Ancestors)

Mental DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 21, 2017

First Posted

November 30, 2017

Study Start

May 31, 2016

Primary Completion

March 30, 2017

Study Completion

December 30, 2018

Last Updated

November 30, 2017

Record last verified: 2017-11

Locations