Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

NCT03354676 | Completed DMC

• 1 other identifier: 12870
• Study Type: observational
• Target: 122
• Locations: 0 countries
• Sites: N/A

Brief Summary

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Conditions

Obesity, Metabolically Benign

Keywords

adipokines, metabolic syndrome, obese children

Outcome Measures

Primary Outcomes (4)

• Defining obesity in the pediatric population

  Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph.

  Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.

• Leptin changes in the obese children with metabolic syndrome

  Evaluating leptin in the obese group with metabolic syndrome

  Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml.

• Adiponectin changes in the obese children with metabolic syndrome

  Evaluating adiponectin in the obese group with metabolic syndrome

  Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values.

• Assessing cardiovascular risk in the obese children with metabolic syndrome

  Evaluating hsCRP in the obese group with metabolic syndrome

  hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l

Study Arms (2)

MetS+

Obese group with metabolic syndrome/Data processing from Patient Medical Files

Other: MetS+

MetS-

Obese group without metabolic syndrome/Data processing from Patient Medical Files

Other: MetS-

Interventions

MetS- OTHER

Data processing from Patient Medical Files

MetS-

Eligibility Criteria

• Age: 4 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

All children admitted to the Endocrinology, Diabetology and Cardiology Department who met the Inclusion Criteria

You may qualify if:

• obese children (BMI\> 95th percentile)

You may not qualify if:

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Sponsors & Collaborators

• Alexandru Florin Rogobete: lead
• University of Medicine and Pharmacy "Victor Babes" Timisoara: collaborator

Related Publications (3)

• Beyazit F, Unsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. No abstract available.

  PMID: 28890432 BACKGROUND

• Lopez-Quintero A, Garcia-Zapien AG, Flores-Martinez SE, Diaz-Burke Y, Gonzalez-Sandoval CE, Lopez-Roa RI, Medina-Diaz E, Munoz-Almaguer ML, Sanchez-Corona J. Contribution of polymorphisms in the LEP, LEPR and RETN genes on serum leptin and resistin levels in young adults from Mexico. Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):10-18. doi: 10.14715/cmb/2017.63.8.3.

  PMID: 28886308 BACKGROUND

• Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2018 Jul;55(4):422-429. doi: 10.1177/0004563217733286. Epub 2017 Nov 23.

  PMID: 28882065 BACKGROUND

MeSH Terms

Conditions

Obesity, Metabolically Benign; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Officials

• Alexandru Florin Rogobete, PhDS

  Romanian Society of Anesthesia and Intensive Care

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MSc, PhDs, Clinical Researcher

Study Record Dates

• First Submitted: September 12, 2017
• First Posted: November 28, 2017
• Study Start: March 11, 2016
• Primary Completion: August 11, 2017
• Study Completion: September 10, 2017
• Last Updated: November 28, 2017

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share