NCT03352908

Brief Summary

The purpose of this study is to determine if the Yale Swallow Protocol is an effective screen for aspiration in recently extubated patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
166

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 2017

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 25, 2017

Completed
5 days until next milestone

First Submitted

Initial submission to the registry

October 30, 2017

Completed
25 days until next milestone

First Posted

Study publicly available on registry

November 24, 2017

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 29, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 29, 2020

Completed
Last Updated

September 14, 2021

Status Verified

September 1, 2021

Enrollment Period

3 years

First QC Date

October 30, 2017

Last Update Submit

September 10, 2021

Conditions

Keywords

DysphagiaAspirationYSPFEESSwallow Problems

Outcome Measures

Primary Outcomes (1)

  • Determine the sensitivity of the Yale Swallow Protocol (YSP) through aspiration identification in recently extubated patients.

    Participants will receive FEES and YSP in a randomized order within a 2 hours of one another. Sensitivity estimates and analysis will be obtained through confidence intervals

    Assessing the sensitivity of YSP within 2 study visit, within 2 hours. Data will be reported at study completion, an average of 1 year.

Study Arms (2)

YSP

The Yale Swallow Protocol (YSP) consists of a brief cognitive screen, a brief oral motor exam, and a 3oz water challenge (subjects instructed to drink 3oz of water without stopping). Pass/fail is determined based on the subjects ability to drink the 3oz of water uninterrupted without immediate cough.

FEES

Flexible Endoscopic Evaluation of Swallowing (FEES) uses a flexible endoscope that will be passed transnasally into the pharynx by a speech pathologist specializing in dysphagia management. FEES will be treated as a placebo comparator.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Inpatients recently extubated that are consulted for swallowing assessment by their treating physician.

You may qualify if:

  • Intubation greater than 24 hours
  • Age 18 and older
  • All races
  • Males and females
  • English speaking
  • Swallow consult ordered by the team within 48 hours of extubation

You may not qualify if:

  • Known history of oropharyngeal dysphagia
  • Contraindication for FEES due to facial fractures, nothing by mouth (NPO) status for other procedures, elevated bleeding risk, reduced level of alertness, or significant agitation.
  • Allergy to dairy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Wisconsin - Madison

Madison, Wisconsin, 53792, United States

Location

MeSH Terms

Conditions

Deglutition Disorders

Condition Hierarchy (Ancestors)

Esophageal DiseasesGastrointestinal DiseasesDigestive System DiseasesPharyngeal DiseasesOtorhinolaryngologic Diseases

Study Officials

  • Stevie J Marvin, MS

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 30, 2017

First Posted

November 24, 2017

Study Start

October 25, 2017

Primary Completion

October 29, 2020

Study Completion

October 29, 2020

Last Updated

September 14, 2021

Record last verified: 2021-09

Locations