Hospital-acquired Pneumonia in Intensive Care Unit

NCT03348579 | Completed

• 1 other identifier: RC17_0434
• Study Type: observational
• Target: 1,850
• Locations: 1 country
• Sites: 1

Brief Summary

hospital-acquired pneumonia are a common disease in intensive care unit. The prevention, the diagnosis and the treatment of hospital acquired pneumonia are a frequent challenge. Nevertheless it seems that there are great differences in standard of care between hospitals. The investigators hypothesized that medical education and implementation of evidence-base guidelines can reduce the duration of mechanical ventilation in patients presenting of hospital acquired pneumonia

Conditions

Hospital Acquired Pneumonia; Ventilator-Associated Pneumonia; Sepsis; Pneumonia

Keywords

Intensive care unit; Pneumonia; Ventilator associated; Hospital acquired pneumonia; Guidelines

Outcome Measures

Primary Outcomes (1)

• Unit length of stay

  Duration of ICU hospitalization Safety Issue: NA

  28 days

Secondary Outcomes (4)

• Intensive Care Unit free-days at day 28

  28 days

• Hospital-acquired pneumonia

  28 days

• Composite measure of compliance to guidelines

  28 days

• Empirical treatment failure

  28 days

Study Arms (3)

The before period

The before period (control phase) will consist of all consecutive patients admitted to the participating ICUs before the national guidelines publication concerning hospital-acquired pneumonia.

Other: Guidelines publication and application

The second period

Intensive care units are randomized in two groups: Standard training: The centers will receive the text of the recommendation electronically. The principal investigator of each center will then train doctors, interns, nurses and physiotherapists to the use of these recommendations (team leader). A computer presentation common to all the centers will be used and a communication strategy vis-à-vis the other caregivers of the investigative services will be put in place. All doctors, interns and nurses must have attended this theoretical training during the awareness phase.

Other: Guidelines publication and application; Other: Targeted experience feedback

The third and final period

The third and final period will consist of all consecutive patients admitted to the participating ICUs after the formal training.

Other: Guidelines publication and application

Interventions

Guidelines publication and application OTHER

Passing recommendations on using the guidelines in the intensive care units

The before period; The second period; The third and final period

Targeted experience feedback OTHER

Targeted experience feedback": On top of the standard training, the centers receive an analysis of the evolution of the practices of their center and the future of their patients between phases 1 and 2, as well as these same values for the data set. The centers are then called to conduct a meeting to determine their priority improvement points based on this audi

The second period

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

adult patients hospitalized in intensive care units with a hospital stay greater than 72 hours and a GIs-II greater than or equal to 15.

You may qualify if:

• Age \> 18 years ; IGS-II score \> 15 ; Hospital stay \>= 3 days

You may not qualify if:

• Community-acquired pneumonia, pregnant women, refusal to participate

Sponsors & Collaborators

• Nantes University Hospital: lead
• Société Française d'Anesthésie et de Réanimation: collaborator

Study Sites (1)

CHU de NANTES

Nantes, 44093, France

Location

Related Publications (1)

• Roquilly A, Chanques G, Lasocki S, Foucrier A, Fermier B, De Courson H, Carrie C, Danguy des Deserts M, Gakuba C, Constantin JM, Lagarde K, Holleville M, Blidi S, Sossou A, Cailliez P, Monard C, Oudotte A, Mathieu C, Bourenne J, Isetta C, Perrigault PF, Lakhal K, Rouhani A, Asehnoune K, Guerci P, Tran Dinh A, Chousterman B, Cupaciu A, Dahyot-Fizelier C, Bellier R, Au Duong J, Mansour A, Morel J, Beauplet G, Vibet MA, Feuillet F, Sebille V, Leone M. Implementation of French Recommendations for the Prevention and the Treatment of Hospital-acquired Pneumonia: A Cluster-randomized Trial. Clin Infect Dis. 2021 Oct 5;73(7):e1601-e1610. doi: 10.1093/cid/ciaa1441.

  PMID: 32970811 DERIVED

MeSH Terms

Conditions

Healthcare-Associated Pneumonia; Pneumonia, Ventilator-Associated; Sepsis; Pneumonia

Condition Hierarchy (Ancestors)

Cross Infection; Infections; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Systemic Inflammatory Response Syndrome; Inflammation

Study Officials

• Antoine Roquilly, PH

  Nantes University Hospital

  PRINCIPAL INVESTIGATOR

• Marc Leone

  AP-HM

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2017
• First Posted: November 21, 2017
• Study Start: September 15, 2017
• Primary Completion: October 15, 2018
• Study Completion: December 15, 2018
• Last Updated: May 12, 2020

Record last verified: 2017-11

Locations

FR (1)