Is Optimal Minute Ventilation a Predictor of Weaning in Patients With Prolong Mechanical Ventilation?

NCT03348085 | Completed

• 1 other identifier: 04-XD25-067
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.purpose of study: optimal minute could be the prediction of successful weaning and become the new weaning parameter.
2. 2.study design: inclusion criteria: investigators will perform this study at our respiratory care center. Patients who had been maintained on mechanical ventilator in excess of 3 weeks before respiratory care center admission and all previous weaning attempts had ailed.
3. 3.study duration: 2016/01/01\~12/31

Conditions

Chronic Respiratory Failure

Outcome Measures

Primary Outcomes (1)

• The prediction of optimal minute ventilation as successful weaning parameters in patients with prolong mechanical ventilator.

  Investigators observed the condition of patients with adaptive spontaneous ventilation mode that the patient admitted to respiratory care center first day

  2016/01/01~2016/12/31,1 year

Interventions

No intervention OTHER

No intervention.

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients are included in this study if they had been maintained on mechanical ventilation in excess of 3 weeks before respiratory care center admission, and all previous weaning attempts had failed. Patients are eligible for respiratory care center admission : hemodynamics stability, no vasoactive drug infusion for 24 hours or more before transfer, stable oxygen requirements(FIO2\<40%,PERP\<10 cmH2O), no hepatic failure, no requirement for surgical intervention within the 2 weeks, .

You may qualify if:

• patients who had been maintained on mechanical ventilation in excess of 3 weeks before respiratory care center admission and all previous weaning attempts had failed.

You may not qualify if:

• Patients do not have spontaneous breath. Patients do not use invasive mechanical ventilator. Terminal cancer stage and hemodynamics unstable.

Sponsors & Collaborators

• Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation: lead

Related Publications (11)

• Ntoumenopoulos G. Rehabilitation during mechanical ventilation: Review of the recent literature. Intensive Crit Care Nurs. 2015 Jun;31(3):125-32. doi: 10.1016/j.iccn.2015.02.001. Epub 2015 May 27.

  PMID: 26026495 BACKGROUND

• MacIntyre NR, Epstein SK, Carson S, Scheinhorn D, Christopher K, Muldoon S; National Association for Medical Direction of Respiratory Care. Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference. Chest. 2005 Dec;128(6):3937-54. doi: 10.1378/chest.128.6.3937.

  PMID: 16354866 BACKGROUND

• King C, Moores LK. Controversies in mechanical ventilation: when should a tracheotomy be placed? Clin Chest Med. 2008 Jun;29(2):253-63, vi. doi: 10.1016/j.ccm.2008.01.002.

  PMID: 18440435 BACKGROUND

• Scheinhorn DJ, Artinian BM, Catlin JL. Weaning from prolonged mechanical ventilation. The experience at a regional weaning center. Chest. 1994 Feb;105(2):534-9. doi: 10.1378/chest.105.2.534.

  PMID: 8306758 BACKGROUND

• Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, Zhu J, Sachdeva R, Sonnad S, Kaiser LR, Rubinstein NA, Powers SK, Shrager JB. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008 Mar 27;358(13):1327-35. doi: 10.1056/NEJMoa070447.

  PMID: 18367735 BACKGROUND

• Frutos-Vivar F, Esteban A. Critical illness polyneuropathy: a new (or old?) reason for weaning failure. Crit Care Med. 2005 Feb;33(2):452-3. doi: 10.1097/01.ccm.0000153525.37281.d4. No abstract available.

  PMID: 15699857 BACKGROUND

• Wu YK, Tsai YH, Lan CC, Huang CY, Lee CH, Kao KC, Fu JY. Prolonged mechanical ventilation in a respiratory-care setting: a comparison of outcome between tracheostomized and translaryngeal intubated patients. Crit Care. 2010;14(2):R26. doi: 10.1186/cc8890. Epub 2010 Mar 1.

  PMID: 20193057 BACKGROUND

• Schonhofer B. [Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously]. Pneumologie. 1997 Jun;51(6):599-600. No abstract available. German.

  PMID: 9333795 BACKGROUND

• Verceles AC, Diaz-Abad M, Geiger-Brown J, Scharf SM. Testing the prognostic value of the rapid shallow breathing index in predicting successful weaning in patients requiring prolonged mechanical ventilation. Heart Lung. 2012 Nov-Dec;41(6):546-52. doi: 10.1016/j.hrtlng.2012.06.003. Epub 2012 Jul 6.

  PMID: 22770598 BACKGROUND

• Wu CP, Lin HI, Perng WC, Yang SH, Chen CW, Huang YC, Huang KL. Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failure. Respir Care. 2010 Mar;55(3):334-41.

  PMID: 20196884 BACKGROUND

• OTIS AB, MCKERROW CB, BARTLETT RA, MEAD J, MCILROY MB, SELVER-STONE NJ, RADFORD EP Jr. Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol. 1956 Jan;8(4):427-43. doi: 10.1152/jappl.1956.8.4.427. No abstract available.

  PMID: 13286206 BACKGROUND

Study Officials

• YaRu Liang

  Taipei Tzuchi hospital , Buddhist Tzu chi medical foundation

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2017
• First Posted: November 20, 2017
• Study Start: January 1, 2016
• Primary Completion: December 31, 2016
• Study Completion: December 31, 2016
• Last Updated: November 24, 2017

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share