miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

NCT03344744 | Completed

• 1 other identifier: miSAH003
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Conditions

Subarachnoid Hemorrhage

Keywords

Subarachnoid Haemorrhage

Outcome Measures

Primary Outcomes (1)

• Circulating micro RNA concentrations

  Serum micro RNA concentrations

  Day 3

Secondary Outcomes (3)

• Circulating micro RNA change

  Days 1,2,3,7

• Cerebrospinal fluid micro RNA concentrations

  Day 1,2,3,7

• Cerebrospinal fluid micro RNA change

  Days 1,2,3,7

Study Arms (3)

SAH with DCI

Aneurysmal subarachnoid haemorrhage patients with delayed cerebral infarction

SAH nonDCI

Aneurysmal subarachnoid haemorrhage patients without delayed cerebral infarction

Control

Healthy volunteers

Eligibility Criteria

• Age: 21 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Acute aneurysmal subarachnoid hemorrhage patients with and without delayed cerebral infarction * Healthy volunteers

You may qualify if:

• Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

You may not qualify if:

• Previous neurological diseases such as stroke or dementia

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Department of Surgery, The Chinese University of Hong Kong

Hong Kong, China

Location

Related Publications (3)

• Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC. Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc. 2017 Apr 25;6(4):e005363. doi: 10.1161/JAHA.116.005363.

  PMID: 28442458 BACKGROUND

• Su XW, Chan AH, Lu G, Lin M, Sze J, Zhou JY, Poon WS, Liu Q, Zheng VZ, Wong GK. Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage. PLoS One. 2015 Dec 16;10(12):e0144724. doi: 10.1371/journal.pone.0144724. eCollection 2015.

  PMID: 26675167 BACKGROUND

• Wong GK, Lam S, Ngai K, Wong A, Mok V, Poon WS; Cognitive Dysfunction after Aneurysmal Subarachnoid Haemorrhage Investigators. Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors and correlations with 3 month outcomes. J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1112-7. doi: 10.1136/jnnp-2012-302217. Epub 2012 Jul 31.

  PMID: 22851612 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• George KC Wong

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor(Clinical)

Study Record Dates

• First Submitted: October 12, 2017
• First Posted: November 17, 2017
• Study Start: November 30, 2017
• Primary Completion: August 31, 2023
• Study Completion: August 31, 2023
• Last Updated: September 7, 2023

Record last verified: 2023-09

Locations

CN (1)