Epidemiology of Resistant Microbial Strains Among Different Groups of People (Healthy, Infected and Exposed to Animals)

NCT03343119 | Unknown

• 1 other identifier: SLOTI12038T
• Study Type: observational
• Target: 708
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study investigates carriage rate and risk factors for acquiring multiresistant bacteria (ESBL producing E.coli and K.pneumoniae, carbapenem-resistant and multidrug resistant P.aeruginosa, MRSA and VRE) in hospitalised patients and healthy volunteers.

Conditions

ESBL Producing E.Coli; ESBL Producing K.Pneumoniae; Multidrug Resistant P.Aeruginosa; Carbapenem Resistant P.Aeruginosa; Methicillin Resistant Staphylococcus Aureus (MRSA); Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)

Outcome Measures

Primary Outcomes (2)

• Colonization rate with multiresistant (MDR) bacteria in hospitalized patients

  To evaluate the impact of hospitalization for carriage and infection rate with MDR bacteria

  March 2012 - March 2014

• Colonization rate with multiresistant (MDR) bacteria in healthy humans

  To evaluate the impact of animal exposure for carriage rate with MDR bacteria

  March 2012 - March 2014

Study Arms (5)

Hospitalised patients

No intervention

Healthy volunteers

No intervention

Dog owners (healthy volunteers)

No intervention

Veterinarians (healthy volunteers)

No intervention

Pig farmers (healthy volunteers)

No intervention

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

I group All individuals who have been hospitalised and have been diagnosed carriage or infection with multiresistant bacteria listed above. II group Children \>6 months of age and all adults who have not been hospitalised or received antibacterial treatment in previous 3 months.

You may qualify if:

• MDR bacteria (listed above) isolated from clinical specimen
• hospitalisation to the Tartu University Hospital or North Estonia Medical Centre or West Tallinn Central Hospital or East-Tallinn Central Hospital or The Hospital of Reconstructive Surgery
• age \>6 months
• have not received any antibacterial treatment in previous 3 months
• have not been hospitalised in previous 3 months
• age \>6 months
• have not received any antibacterial treatment in previous 3 months
• have not been hospitalised in previous 3 months
• owning a dog
• have not received any antibacterial treatment in previous 3 months
• have not been hospitaliZed in previous 3 months
• working as a veterinarian
• have not received any antibacterial treatment in previous 3 months
• have not been hospitalized in previous 3 months
• occupation as a pig farmer

Sponsors & Collaborators

• University of Tartu: lead
• Estonian University of Life Sciences: collaborator

Related Publications (1)

• Telling K, Laht M, Brauer A, Remm M, Kisand V, Maimets M, Tenson T, Lutsar I. Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals. BMC Infect Dis. 2018 Oct 11;18(1):513. doi: 10.1186/s12879-018-3421-1.

  PMID: 30309321 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

DNA from isolated multiresistant bacteria

Study Officials

• Tanel Tenson, PhD

  University of Tartu

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: November 8, 2017
• First Posted: November 17, 2017
• Study Start: March 27, 2012
• Primary Completion: January 30, 2014
• Study Completion: August 1, 2019
• Last Updated: October 11, 2018

Record last verified: 2018-10